天津医药

• 实验研究 •    

替米沙坦对胰岛素抵抗OLETF大鼠血清单核细胞趋化蛋白1表达的影响

姚瑞栋1,田凤石2,雒瑢3,赵紫琴4,郑喜兰4   

  1. 1. 天津医科大学研究生院2007级硕士研究生临床八班1302宿舍
    2. 天津市公安医院
    3. 天津医科大学内分泌研究所
    4. 00
  • 收稿日期:2009-12-22 修回日期:2010-02-03 出版日期:2010-05-15 发布日期:2010-05-15
  • 通讯作者: 姚瑞栋

Effect of Telmisartan on The Expression of MCP-1 in OLETF Rats With Insulin Ressitance

  • Received:2009-12-22 Revised:2010-02-03 Published:2010-05-15 Online:2010-05-15

PDF (PC)

1945

摘要： [摘要] 目的 探讨血管紧张素Ⅱ1型 (AT1）受体阻滞剂替米沙坦对胰岛素抵抗的OLETF（otsuka long—evans tokushima fatty）大鼠血清单核细胞趋化蛋白1（MCP-1）表达的影响及意义。方法 OLETF雄性大鼠20只，高脂喂养32周诱导建立胰岛素抵抗大鼠模型。20只胰岛素抵抗的OLETF大鼠随机分为两组，每组10只：①模型组（MX）：高脂饮食。②替米沙坦组（MT）：高脂饮食加替米沙坦。干预16周后测定空腹血糖（FBG）、血清胰岛素(FINS)、游离脂肪酸（FFA）、血脂及单核细胞趋化蛋白1（MCP-1）水平。结果 替米沙坦有改善胰岛素抵抗和糖、脂代谢的作用，替米沙坦组与模型组比较，血清MCP-1表达水平明显降低（t=2.88,P<0.05）。结论 替米沙坦可能通过抑制血清炎症因子MCP-1的表达改善血糖、胰岛素抵抗（IR）。

关键词: 替米沙坦, 游离脂肪酸, 血脂, 胰岛素抵抗, OLETF大鼠, 单核细胞趋化蛋白1

Abstract: Abstract Objective To investigate the changes of MCP-1 in OLETF rats with Insulin Resistance and whether angiotensin II type／(AT1)receptor blocker，Telmisartan has a protective effect by influencing MCP-1 expression．Methods 22 male OLETF rats were fed with high-fat diet for 32 weeks to establish the insulin resistance model with hyperlipidemia。the 20 male OLETF rats with insulin resistance model were randomly assigned into two groups:①the model group,in which the rats were fed with high-diet;②the Telmisartan group,in which the rats were fed with high-diet and Telmisartan .After 16 weeks of drug intervention,MCP-1,fasting blood glucose,fasting insulin,FFA and lipid level in plasma were measured.Results After the OLETF rats were treated for 16 weeks with Telmisartan , Telmisartan can improve insulin resistance and lipid metabolism .the serum MCP-1 was significantly lower than that of the model group(p<0.05).Conclusion Telmisartan can improve IR、blood glucose and the mechanism might be that it could inhibit the MCP-1 expression in serum.

Key words: Telmisartan, free fatty acid, Lipid, insulin resistance, OLETF rats, MCP-1