天津医药

• 短篇论著 • 上一篇    下一篇

食物不耐受在腹泻型肠易激综合征中的作用

郭虹1,江涛2,王金梁3   

  1. 1. 河南科技大学第一附属医院消化内科
    2.
    3. 河南科技大学第一附属医院医务科
  • 收稿日期:2010-11-18 修回日期:2011-02-23 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 王金梁

Role of food intolerance in irritable bowel syndrome with diarrhea

  • Received:2010-11-18 Revised:2011-02-23 Published:2011-10-15 Online:2011-10-15

PDF (PC)

2179

摘要： 目的: 研究腹泻型肠易激综合征（IBS-D）患者食物不耐受的发病状况, 为肠易激综合征的防治提供理论依据。方法: 选取符合罗马III标准的IBS-D患者77例，健康对照组26例，采用酶联免疫方法,半定量测定血清中14种食物抗原的特异性IgG抗体。结果: IBS-D患者组血清食物特异性IgG抗体阳性率为50.6% ，健康对照组为15.4%，两组间比较有统计学意义(P< 0.01)，两组间食物特异性IgG抗体阳性程度亦存在统计学差异（Z=-3.220,P=0.001）。在14种食物中，IBS-D患者IgG抗体检测结果阳性率依次为: 蛋清/蛋黄（32.5% ）＞西红柿（14.3% ）＞ 蟹（9.1% ）＞ 牛奶、大豆（6.5%）＞蘑菇（3.9%）＞玉米（2.6%）＞大米、小麦、 鳕鱼、鸡肉（1.3%）。健康对照组血清中仅蛋清/蛋黄、牛奶和西红柿特异性IgG抗体水平轻度增高。结论:食物介导的体液免疫反应异常即食物不耐受在IBS-D的发病机制中具有重要的作用。

关键词: 腹泻型肠易激综合征, 食物不耐受, 免疫球蛋白G

Abstract: 【Abstract】　Objective: To investigate the etiopathological role and mechanism of food intolerance in the diseases of irritable bowel syndrome with diarrhea ( IBS-D) in order to provide a diagnosis bases for clinical diagnosis and treatment of the diseases.Methods: The specific IgG antibodies of 14 kind of different food antigens in serum were detected by the enzyme linked immunosorbant assay (ELISA) in seventy seven cases of patients in IBS-D with Rome III and twenty six normal controls.Results: The positive rate of serum food-specific IgG antibodies was 50.6 percent in IBS-D and 15.4 percent in normal controls . there was statistically difference between the two groups (P< 0.01). there is also statistically difference between the two groups in IgG antibody levels (Z =- 3.220, P = 0.001). The positive rate of 14 kinds of serum food-specific IgG antibodies in IBS-D were and followed:egg white/yolk （32.5%）＞ tomato（14.3%）＞crab （9.1%）＞milk and soybean（6.5%）＞mushroom （3.9%）＞corn（2.6%）＞rice、 wheat、codfish and chicken（1.3%）.Only low increased levels of specific IgG to egg white/yolk、milk and tomato in normal controls were found and the specific IgG to other foods were negative. Conclusion:The abnormal humoral immune reactionsmediated by food intolerance played an important role in the immunopathogenesis of IBS-D.

Key words: 　Irritable bowel syndrome with diarrhea, Food intolerance, Immunoglobulin IgG