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有机硒降小鼠血糖和血脂作用的实验研究

冯润荷   

  1. 天津医学高等专科学校
  • 收稿日期:2010-12-08 修回日期:2011-02-16 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 冯润荷

Organic selenium lowering blood glucose and blood lipid in rats

Runhe FENG   

  • Received:2010-12-08 Revised:2011-02-16 Published:2011-10-15 Online:2011-10-15
  • Contact: Runhe FENG

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摘要： 目的：探讨有机硒对高血糖小鼠降血糖作用和高脂血症小鼠降血脂作用。方法：（1）小鼠60只随机均分为3组，对照组、病理模型组和治疗组，治疗组给予有机硒蛋白粉，对照组给予等容积的自来水，末次给药后取血，测定空腹血糖含量。（2）小鼠60只随机均分为3组，对照组、高脂模型组和治疗组，治疗组给予有机硒蛋白粉，对照组和高脂模型组给予等容积的自来水。末次给药后2h,除对照组外，高脂模型组和治疗组小鼠均腹腔注射75%蛋黄乳；20h后取血，测定小鼠血清TC、HDL、LDL、TG的含量。结果：（1）制备糖尿病模型成功，病理模型组和治疗组小鼠血糖含量均极显著高于对照组；治疗组小鼠血糖含量极显著低于病理模型组。（2）高脂模型组小鼠TC、LDL和TG含量均显著高于治疗组和对照组；治疗组小鼠血清TC、LDL、TG含量均显著低于高脂模型组，治疗组小鼠血清TC、LDL、TG含量均极显著或显著高于对照组。结论：有机硒蛋白粉具有显著降低高脂血症小鼠血脂和糖尿病小鼠血糖的作用。

关键词: 有机硒, 血糖, 血脂

Abstract: ABSTRACT Objective: To investigate the organic selenium on the hypoglycemic effect of high glucose in mice and hyperlipidemic mice with lipid-lowering effect. Methods: (1) 30 mice were randomly divided into 3 groups, control group, pathological model group and treatment group, treatment group received organic selenium protein powder, the control group received the same volume of water, taken after the last administration of blood to determine fasting blood glucose levels. (2) 30 mice were randomly divided into 3 groups, control group, high fat model group and treatment group, treatment group received organic selenium protein powder, fat control group and model group were given equal volume of water. After the last administration 2h, except control group, model group and treatment group mice were injected 75% egg yolk; 20h after the blood, serum TC, HDL, LDL, TG content. Results: (1) to prepare a successful model of diabetes, pathological model group and treatment group blood glucose levels were significantly higher; blood sugar treatment group was significantly lower than the pathological model group. (2) hyperlipidemia model group TC, LDL and TG were significantly higher than the treatment group and control group; treatment of the serum TC, LDL, TG levels were significantly lower than model group, treatment group, serum TC, LDL, TG levels were significantly higher or significantly. Conclusion: Organic selenium protein powder significantly reduced serum lipids and the role of blood glucose in diabetic mice.

Key words: Organic selenium, glucose, lipid