天津医药

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肥胖儿童白细胞计数与糖脂代谢及心血管危险因素的关系

高芳芳1,刘戈力2,杨箐岩1,郑荣秀1,姜丽红2,鲍鹏丽1,魏莹1   

  1. 1. 天津医科大学总医院
    2. 天津医科大学总医院儿科
  • 收稿日期:2010-08-16 修回日期:2010-11-17 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 高芳芳

Association of white blood cell count with glucose and lipid metabolism and cardiovascular risk factors in obese children

  • Received:2010-08-16 Revised:2010-11-17 Published:2011-05-15 Online:2011-05-15

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摘要： 摘要： 目的 探讨肥胖儿童白细胞计数与糖脂代谢及心血管危险因素的关系。方法 收集分析2009年7月至2010年6月于天津医科大学总医院儿科内分泌门诊8 -15岁肥胖儿童111例，其中男孩84例，女孩27例。将白细胞计数分为四层（WBCC1，最低；WBCC4，最高），分别比较男孩、女孩各组糖脂代谢指标。对年龄及BMI进行校正后采用偏相关分析肥胖儿童不同性别WBCC与糖脂代谢及心血管危险因素的关系，分析影响WBC计数水平的指标采用多元逐步回归分析。结果 男孩白细胞计数、BMI、WC及TG高于女孩，而SBP、DBP、FPG、HDL-C、LDL-C、TC、HOMA-IR及致动脉粥样硬化指数则无统计学差异。男孩及女孩的WBCC4组WC及BMI均高于WBBC1组，男孩WBCC4组TG及致动脉粥样硬化指数高于WBCC1组，WBCC4组的HDL低于WBCC1、WBCC2组(P<0.05)。男孩WBCC与BMI、WC、TG及致动脉粥样硬化指数呈正相关(P<0.05)；女孩WBCC与BMI与WC呈正相关(P<0.05)。多元逐步回归结果显示影响白细胞计数的主要因素为TG、WC、HDL-C。结论 白细胞计数作为炎症标志物，与中心性肥胖、血脂异常及糖代谢紊乱关系密切，肥胖儿童白细胞计数水平升高可能成为心血管疾病的重要危险因素之一，参与了糖脂代谢紊乱及心血管疾病的发生发展过程。

关键词: 儿童, 白细胞计数, 糖脂代谢, 心血管危险因素

Abstract: Abstract Objective: To investigate Association of white blood cell count (WBCC) with glucose and lipid metabolism and cardiovascular risk factors in obese children. Methods: A total of 111 subjects,84 boys and 27girls aged 8 – 15 years were enrolled. The subjects were divided into four quartiles according to WBCC (WBCC1 – 4, from the lowest to highest WBCC) in both genders. The mean values of glucose and lipid metabolism and cardiovascular risk factors for each group were compared in boys and girls separately. Bivariate correlation analysis used to compare the relationship between WBCC and glucose and lipid metabolism and cardiovascular risk factors. Multiple regression analysis used to evaluate the factors affecting the level of WBC count. ResultS: The boys had signi?cantly higher WBCC, BMI, WC and triglyceride (TG) than the girls. While there was no significant differences in the systolic blood pressure（SBP）, diastolic blood pressure（DBP）,fasting blood glucose(FPG), high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (HDL-C).，total cholesterol(TC). When comparing the risks of the quartiles of WBCC, In both genders, WBCC4 had signi?cant higher the BMI and WC than WBCC1.In addition, TG and AI of WBCC4 was signi?cantly higher than WBCC1 while HDL-C of WBCC4 was lower than WBCC1 and WBCC2 in boys. WBCC was positively related with BMI, WC,TG,AI and negatively related with HDL-C among boys, whereas in girls only BMI and WC was positively related with WBCC. Multiple stepwise regression analysis showed that the main factors affecting white blood cell count for the TG, WC, HDL-C. Conclusions：White blood cell count as a marker of inflammation, the ravelence of it and central obesity, dyslipidemia and glucose metabolism are closely. Elevated white blood cell count in obese children could become an important cardiovascular disease risk factors, involved in lipid disorders and cardiovascular diseases development.

Key words: children, glucose and lipid metabolism, white blood cell count, cardiovascular risk factors

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