天津医药

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肝移植术后早期口腔并发症及深部真菌感染的预防

李萌萌1,李荣华2,殷恺1,3,3,曹晓丽4   

  1. 1. 天津市第一中心医院
    2. 天津市第一中心医院口腔科
    3. 天津市和平区哈密道128号 康达公寓B14-3
    4. 天津医科大学研究生院；天津市第一中心医院口腔科
  • 收稿日期:2010-12-22 修回日期:2011-03-07 出版日期:2011-06-15 发布日期:2011-06-15
  • 通讯作者: 李萌萌

Clinical Research of Prevention prophase oral cavity infection and deep fungal infection after liver transplantion

  • Received:2010-12-22 Revised:2011-03-07 Published:2011-06-15 Online:2011-06-15

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摘要： [摘要] 目的：观察研究口腔内局部联合用药预防肝移植术后早期口腔感染及深部真菌感染的临床效果。 方法 ：将162例肝移植术后患者随机分为观察组A（57例）、观察组B（62例）和对照组C（43例）,观察组A采用3%碳酸氢钠溶液和0.1%西吡氯铵含漱液局部交替应用进行口腔干预，观察组B采用5万U/ml制霉菌素水混悬液和0.1%西吡氯铵含漱液局部交替应用进行口腔干预，对照组C常规采用生理盐水进行口腔干预，观察并记录患者术后口腔并发症，并进行血浆(1→3)-β-D葡聚糖水平检测。 结果：观察组A和观察组B口腔并发症及(1→3)-β-D葡聚糖水平均明显低于对照组C,差异有显著性（P<0.05）,观察组A和观察组B两组之间口腔并发症和(1→3)-β-D葡聚糖水平差异无统计学意义（P>0.05）。 结论：采用0.1%西吡氯铵含漱液分别与3%碳酸氢钠溶液和5万U/ml制霉菌素水混悬液联合应用进行口腔干预对预防肝移植术后早期口腔并发症及深部真菌感染有重要意义。

关键词: 肝移植, 口腔并发症, 深部真菌感染, 局部用药

Abstract: [Abstract] Objective To observe the clinical effect of durg combination use in oral cavity on prevention of prophase oral infection and deep fungal infenction after liver transplantion. Methods To choose 162 liver transplantation patients were randomly divided into observation groupA(n=57), observation group B(n=62)and control group C(n=43)，For the experiment group , alternately use 3% sodium bicarbonate gargle and 0.1% cetylpyridinium chloride gargle to cavity nursing, And observation group B use 50000 U/ml nystatin aqueous suspension combine with 0.1% cetylpyridinium chloride gargle in turn to oral nursing, control group C only with normal saline nursing oral cavity ,then the oral complication in every groups was investigated,and make plasma (1-3)-β-D-glucan test. Results The oral complication and (1-3)-β-D-glucan test level were no difference between observation groupA and observation group B(P＞0.05);but showed significant differentces between observation groupA and observation group B to contrast control group C (P＜0.05). Conclusions There were important meaning in use 0.1% cetylpyridinium chloride gargle combine with 3% sodium bicarbonate gargle and 50000 U/ml nystatin aqueous suspension respectively to oral nursing, on prevention of prophase oral infection and deep fungal infenction after liver transplantion.

Key words: liver transplantation, oral complication, deep fungal infection, local application