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老龄急性冠脉综合征患者血尿酸水平及相关因素分析

郭倩玉1,卢成志2,夏大胜3,陈欣1   

  1. 1. 天津市第一中心医院心内科
    2. 天津市第一中心医院
    3. 第一中心医院心内科
  • 收稿日期:2011-11-21 修回日期:2012-04-17 出版日期:2012-10-15 发布日期:2012-10-15
  • 通讯作者: 郭倩玉

Serum uric acid levels and related factors in elderly patients with acute coronary artery syndrom

  • Received:2011-11-21 Revised:2012-04-17 Published:2012-10-15 Online:2012-10-15

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摘要： 摘要 目的：探讨老龄急性冠脉综合征（ACS）患者血尿酸(UA)水平与ACS临床类型、冠状动脉病变程度以及血清代谢及炎症指标的关系。方法：连续选择272例75岁及以上的接受冠脉造影检查的ACS患者，分为心绞痛组、急性非ST段抬高心肌梗死（NSTEMI）组、急性ST段抬高心肌梗死(STEMI)组；按冠脉造影结果分为单支病变、双支病变、三支病变组，检测血UA水平和血脂、空腹血糖（FBG）、血肌酐（Cr）、白细胞（WBC）水平。结果：不稳定心绞痛组、NSTEMI、STEMI组UA水平无显著差异；不同冠状动脉病变组间UA无显著差异；UA水平和血三酰甘油(TG)、Cr、WBC显著正相关(P<0．01)，UA和高密度脂蛋白胆固醇(HDL—C)显著负相关(P<0．01)。以UA为因变量行多元回归分析Cr、 HDL-C、 WBC进入回归方程。 结论：75岁及以上ACS患者UA水平和ACS临床类型及冠脉病变程度无关，Cr、 HDL-C 和WBC是UA的独立影响因素。

关键词: 尿酸, 急性冠脉综合征, 老龄, 血脂, 白细胞

Abstract: Abstract Objective: To investigate the association between serum uric acid(UA)levels and different types of ACS, the severity of angiographic coronary artery stenosis and other related factors. Methods: The study group consisted of 272 consecutive patients over 75 years old with unstable angina pectoris or acute ST segment elevated myocardial infarction(STEMI) or non ST segment elevated myocardial infarction (NSTEMI) who underwent coronary angiography. Patients were divided into One, two, three-vessel coronary artery lesion group. Serum uric acid and creatinine level, as well as a fasting lipid profile and fasting blood glucose, were measured in all patients. Results: There were no significant difference in UA level among angina pectoris group, NSTEMI group and STEMI group. No difference of UA level were found among the three groups with different vessels lesion. The UA levels were significantly correlated with levels of Cr ,TG ,WBC positively and correlated with HDL-C levels negatively. Mutiple aggression analysis found that Cr、 HDL-C、 WBC were independently correlated with UA. Conclusions: UA levels were not affected by neither ACS types nor severity of coronary lesion in elderly patients over 75 years. Cr、 HDL-C、WBC were independently related factors of UA.

Key words: serum uric acid, acute coronary artery syndrome, elderly, lipids, white blood cell