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糖尿病脂肪肝患者血浆Vaspin与代谢指标的相关性研究

余红艳1,邸阜生2,王璐1,李强1,贾国瑜1,张洁1,李雪粉1   

  1. 1. 天津市第三中心医院
    2. 天津市第三中心医院内分泌科
  • 收稿日期:2011-10-25 修回日期:2012-06-18 出版日期:2012-11-15 发布日期:2012-11-15
  • 通讯作者: 余红艳

The Study of Relationship between Plasma Vaspin and Metabolism in Patients of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease

  • Received:2011-10-25 Revised:2012-06-18 Published:2012-11-15 Online:2012-11-15
  • Contact: Hong-Yan YU

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摘要： 目的：研究2型糖尿病（T2DM）合并非酒精性脂肪性肝病（NAFLD）患者血浆vaspin水平与代谢指标的关系。方法：采用酶联免疫吸附法（ELISA）检测T2DM合并NAFLD组（A组）、T2DM不合并NAFLD组（B组）和正常对照组（NC组）的血浆vaspin水平，采用间接测热法检测能量代谢指标，同时测定相关的临床指标。结果：B组血浆vaspin水平高于A组和NC组，A组和B组RQ值和碳水化合物氧化率显著低于NC组，而24 h尿氮、静息代谢率（REE）、REE/体质量和脂肪氧化率显著高于NC组（P < 0.05或P<0.01），A、B组间差异均无统计学差异（P > 0.05）。A组血浆vaspin水平与体质量、BMI、REE和性别呈正相关，与呼吸商（RQ）呈负相关；B组血浆vaspin水平与体质量指数（BMI）、腰臀比（WHR）、空腹血糖（FPG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、实测REE、实测REE/体质量、TG呈正相关，与RQ呈负相关。vaspin值为92.4μg/L时可作为预测2型糖尿病患者脂肪肝的风险值。结论：血浆vaspin水平与物质及能量代谢密切相关，并可用来预测2型糖尿病患者脂肪肝的风险。

关键词: Vaspin, 糖尿病, 2型, 非酒精性脂肪性肝病, 静息代谢率, 呼吸商

Abstract: Abstract Objective: To investigate the relationship between the serum vaspin and the metabolism of substance and energy in patients of type2 diabetes mellitus(T2DM) with nonalcoholic fatty liver disease (NAFLD). Methods: The level of the serum vaspin was assayed by enzyme-linked immunosorbent assay (ELISA) in all subjects, patients of T2DM with NAFLD （group A), T2DM without NAFLD（group B）and nomal group（group NC).The indexs of energy metabolism were detected by indirect calorimetry，meanwhile，detect the relating clinical datas . Results: (1)The levels of serum vaspin were significantly increased in group B compared with that of group A and NC(P <0.01), in group A and B, the respiratory quotient (RQ) and oxidation of carbohydrate were significantly lower than in group NC,while the 24 hr urine nitrogen、real resting energy expenditure (REE)、REE/ body wheigt and the oxidation of fat significant higher than the group NC（P < 0.05或P<0.01），but there is no different between group A and B. The level of serum vaspin was positively correlated with body weigt ,body mass index(BMI),REE and sex,meanwhile, it was negatively correlated with respiratory quotient (RQ) in group A; The level of serum vaspin was positively correlated with BMI、waist-to-hip ratio(WHR)、fasting blood glucose (FBG)、fasting insulin（FINS）、homeostasis model assessment of insulin resistance（HOMA-IR）、real REE、real REE/body wheigt and TG, while it was negatively correlated with RQ in group B.The concentration of vaspin is 92.4μg/L could predict the risk of type 2 diabetes mellitus with fatty liver. Conclusion: The level of serum vaspin closely related with the metablism of substance and energy, and vaspin could be use to predict the risk of type 2 diabetes mellitus with fatty liver.

Key words: Vaspin, diabetes mellitus, type 2, nonalcoholic fatty liver disease , real resting energy expenditure, respiratory quotient