天津医药

• 短篇论著 • 上一篇    下一篇

FHIT基因在膀胱移行细胞癌中的表达及意义

张春霆1,刘冉录2,林英立2,徐勇2   

  1. 1. 天津医科大学第二医院，天津泌尿外科研究所
    2. 天津医科大学第二医院泌尿外科
  • 收稿日期:2011-04-26 修回日期:2011-09-11 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 张春霆

Expression and Signification of FHIT Gene in Bladder Transitional Cell Carcinoma

  • Received:2011-04-26 Revised:2011-09-11 Published:2012-02-15 Online:2012-02-15

PDF (PC)

2114

摘要： 摘要 目的 探讨FHIT基因mRNA膀胱移行细胞癌中的表达状况及其意义。方法 应用RT-PCR法对62例膀胱移行细胞癌及相应35个癌旁正常组织进行检测。结果 膀胱移行细胞癌中FHIT基因mRNA的表达明显低于正常组织。且随着病理分级有显著的变化。结论 FHIT基因可能作为预测膀胱移行细胞癌发生、发展的较为可靠的参考指标。

关键词: 膀胱移行细胞癌, RT-PCR, FHIT基因

Abstract: Abstracts Objective: To explore expression and signification of FHIT mRNA in bladder transitional cell carcinoma(BTCC). Methods：We detected the expression of FHITmRNA in BTCC of 62 cases and normal bladder tissues of 35 cases by reverse transcription polymerase chain reaction (RT-PCR). Results：FHITmRNA is higher in the normal tissues than in bladder transitional cell carcinoma(BTCC),and FHIT Gene was relatively with the pathological grade. Conclusion：It is of great important role in the initiation and development of BTCC. FHIT gene may be a reference indicator of bladder transitional cell carcinoma.

Key words: Bladder transitional cell carcinoma, RT-PCR, FHIT gene