天津医药

• 论著 • 上一篇    下一篇

慢性阻塞性肺病患者夜间低氧血症与室性心律失常的关系研究

熊晓琦1,陈世雄2,曾凡军3,刘辉国4,5   

  1. 1. 三峡大学第一临床医学院 湖北省宜昌市中心人民医院
    2. 三峡大学第一临床医学院 宜昌市中心人民医院
    3. 宜昌市中心人民医院
    4.
    5. 华中科技大学同济医学院附属同济医院
  • 收稿日期:2011-08-03 修回日期:2011-12-27 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 陈世雄

The relationship between nocturnal hypoxemia and ventricular arrhythmia in patients with chronic obstructive pulmonary disease

  • Received:2011-08-03 Revised:2011-12-27 Published:2012-06-15 Online:2012-06-15

PDF (PC)

2216

摘要： 目的：探讨慢性阻塞性肺病（COPD）患者夜间室性心律失常与夜间低氧血症的关系。方法： COPD组患者36例和同期体检健康者36例（对照组），进行多导睡眠图（PSG）、24 h动态心电图（Holter）、血气分析、肺功能检测。结果：(1)COPD患者夜间低氧血症的发生19例，对照组均未发生；夜间室性心律失常（VA）的发生率明显高于对照组（58.3%vs5.6%），差异有统计学意义 （P<0.01）。(2)COPD患者夜间低氧血症与VA的发生无相关性（r=-0.077，P=0.646）。(3)COPD患者在快速动眼期（REM）和非快速动眼期（NREM）发生VA的频次[（5.51±0.53）次/h vs（5.58±0.32）次/h]差异无统计学意义（P>0.05）。结论：COPD患者出现夜间低氧血症和VA的比率明显要高于正常人，但COPD患者夜间低氧血症与室性心律失常的发生无相关性。

关键词: 慢性阻塞性肺病, 夜间低氧血症, 室性心律失常, 睡眠时相

Abstract: Objective: The purpose of this study was to investigate the relationship between nocturnal hypoxemia and risk of ventricular arrhythmia (VA) during sleep in patients with chronic obstructive pulmonary disease (COPD). Method: 36 patients with COPD and 36 healthy subjects were selected . All the patients accepted Polysomnography, 24-h Holter electrocardiographic recording, Arterial blood gas analysis and pulmonary function tests. Results : Nocturnal hypoxemia episodes were found in nineteen patients with COPD during sleep but none of the control subjects . The prevalence of VA in patients with COPD was also significantly higher than that observed in healthy subjects( 58.3% vs 5.6% ,P<0.01). No associations were found between VA and nocturnal hypoxemia in patients with COPD (rho=-0.077,P=0.646). No differences were found between during REM and non-REM sleep for the frequency of VA[（5.51±0.53）times/h vs（5.58±0.32）times/h] . Conclusion：Patients with COPD have a higher frequency of VA and nocturnal hypoxemia episodes than health subjects. However, no associations were found between VA and nocturnal hypoxemia in patients with COPD.

Key words: COPD, nocturnal hypoxemia, ventricular arrhythmia, sleep stages