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川崎病合并冠状动脉损害的高危因素分析

付佳1,张宏艳2,杨艳章2   

  1. 1. 武汉市妇女儿童医疗保健中心
    2. 天津市儿童医院
  • 收稿日期:2012-02-15 修回日期:2012-05-09 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 张宏艳

High risk factors of coronary artery lesions caused by Kawasaki disease

Jia FU1,宏艳 张1,   

  • Received:2012-02-15 Revised:2012-05-09 Published:2012-07-15 Online:2012-07-15
  • Contact: 宏艳 张

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摘要： 目的 探讨川崎病合并冠状动脉损害发生的高危因素 方法 对1997年1月-2011年9月在我院确诊的1070例川崎病患儿临床资料进行回顾性分析，用单因素方差分析法筛选川崎病合并冠状动脉损害的相关因素，将筛选的变量行多因素Logistic回归分析，筛选川崎病合并冠状动脉损害的高危因素。 结果 单因素方差分析显示，性别、年龄、丙球使用病程、发热时间、白细胞、血小板、C反应蛋白与川崎病合并冠状动脉损害有关（P<0.05)；进一步多因素Logistic回归分析显示，血小板、CRP、年龄、性别是川崎病合并冠状动脉损害的高危因素(P<0.05)。 结论 年龄小于1岁的男孩，血小板异常增高，高C反应蛋白水平的患儿是川崎病合并冠状动脉损害的高危因素。

关键词: 川崎病, 冠状动脉损害, 回顾性分析, 高危因素

Abstract: 0bjective： To explore the high risk factors of coronary artery lesions(CALs)caused by Kawasaki disease. Methods :Clinical data of 1070 patients with KD admitted in our department from January 1997 to September 2011 were collected and retrospectively reviewed.Risk factors associated with coronary artery lesions including gender，age，duration of fever，use of intravenous gamma immune globulin (IVIG)，white blood cell count(WBC),platelet count(PLT),hematocrit(Hct)， C-reactive protein (CRP),erythrocyte sedimentation rate(ESR),and serum albumin(Alb) were analysed．Chi-square test and Logistic regression were performed． Results: Chi-square test showed that gender，age，duration of fever，timing of IVIG treatment，WBC，CRP,and PLT were significantly related to CALs(P <0.05).Multiple Logistic regression analysis identified CRP ,PLT,age ,sex as risk factors of CALs (P < 0.05)． Conclusions :Less than 1 year old age ,male,and high level of CRP and PLT are the high risk factors of CALs caused by Kawasaki disease．

Key words: Kawasaki disease, coronary artery lesions, Logistic regression, high risk factor