天津医药

• 论著 • 上一篇    下一篇

NO治疗新生儿持续肺动脉高压

孙夫强,段洋,王林   

  1. 天津医科大学第二医院
  • 收稿日期:2012-02-28 修回日期:2012-04-20 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 孙夫强

Nitric oxide in persistent pulmomnar hypertension of newborn

  • Received:2012-02-28 Revised:2012-04-20 Published:2012-07-15 Online:2012-07-15

PDF (PC)

2746

摘要： 【摘要】 目的 探讨吸入一氧化氮(NO)联合高频振荡通气（HF0V）治疗新生儿持续性肺动脉高压（PPHN）。方法 30例肺血管痉挛和6例解剖性血管梗阻PPHN患儿，联合高频振荡通气和吸入NO治疗。NO吸入前、后30分钟及24小时监测氧合指数、血气分析、无创血压、SPAP、心率、平均气道压、经皮测血氧饱和度(TcSaO2)，NO吸入30分钟及24小时测定高铁血红蛋白(MHb)浓度与NO2浓度。结果 Ⅰ组26例（86.67%）患儿治愈，氧合指数明显改善，且无明显副作用。Ⅱ组患儿治疗无效。 结论 肺血管痉挛型PPHN患儿尽早采用最低有效剂量吸入。≥34周早产PPHN患儿可应用高频振荡通气联合NO吸入治疗有效。

关键词: 一氧化氮, 高频振荡通气, 新生儿持续肺动脉高压

Abstract: 【Abstract】 Objective TO study the therapeutic effects of inhaled intric oxide(iNO) and high-frequencey oscillatory ventilation in neonatal perisistent pulmonary hypertension (PPHN).Methods 30 neonates with pulmonary angiospasm and 6 patients with anatomic vascular obstruction were thrapied.During high-frequencey oscillatory ventilation,NO was added into ventilator circle. Oxygenation indes(OI),blood gas analysis,blood pressure,pulmonary arterial systolic pressure(SPAP), heart rate,mean airway pressure(MAP)，saturation of blood oxygen per cutem(TcSaO2),methaemoglobin (MetHb),and nitrogen dioxide (NO2)30 minutes and 24 hours after NO therapy were monitored. Results In group Ⅰtwenty-six (86.67%)neonates survived,the oxygenation were improved.There were no significant adverse reaction.In group Ⅱ,there were no remarkable changes. Conclusion Inhaling minimum effective dosage NO in PPHN with pulmonary angiospam was beneficial as soon as possible. Premature infants(≥34W)who was treated with high-frequencey oscillatory ventilation and NO were effective.

Key words: nitric oxide, high-frequencey oscillatory ventilation, neonatal persistent pulmonary hypertension