天津医药

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地佐辛与芬太尼预防开胸手术患者全麻苏醒期躁动的疗效比较

贺克强,王瑞婷   

  1. 安徽医科大学附属省立医院麻醉科
  • 收稿日期:2011-09-05 修回日期:2012-02-01 出版日期:2012-09-15 发布日期:2012-09-15
  • 通讯作者: 贺克强

Comparison of effects of dezocine and fentanyl preventing the incidence of agitation in adult patients during recovery period after thoracic surgery

  • Received:2011-09-05 Revised:2012-02-01 Published:2012-09-15 Online:2012-09-15

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摘要： 摘要】 目的 比较临床常用剂量的地佐辛与芬太尼预防开胸手术患者全麻苏醒期躁动的有效性和安全性。方法 择期开胸手术患者80例，ASA I～Ⅱ级，随机双盲分为两组，每组40例，手术结束前20min分别静脉注射地佐辛10mg（D组）和芬太尼0.1mg（F组）。观察患者在PACU的RSS躁动评分、躁动发生率、苏醒时间和药物的不良反应。结果 D组和F组的躁动评分和躁动发生率比较无统计学差异（P>0.05）；与F组比较，D组的苏醒时间明显短于F组（P<0.01）；不良反应发生率亦明显低于F组（P<0.05）。结论 临床常用剂量的地佐辛与芬太尼都可有效地预防开胸手术患者全麻苏醒期躁动，但地佐辛的不良反应更少、安全性更高。

关键词: 哌啶类/*投药和剂量, 芬太尼, 胸外科手术

Abstract: 【Abstract】 Objective To compare the effects of usual clinical doses of dezocine and fentanyl preventing the incidence of agitation in adult patients during recovery period after thoracic surgery. Methods Eighty ASA I-Ⅱ patients scheduled for elective thoracic surgery under general anesthesia were randomly，double blindedly divided into two groups with 40 cases each.The patients were administered intravenously dezocine 10mg(group D)and fentanyl 0.1mg(group F) 20min before the end of surgery. The RSS agitation scale, the incidence of agitation,wake-up time and adverse events were assessed．Results The scale and incidence of agitation was no significant difference between group D and F(P>0.05).Compared with group F,the wake-up time of group D was shorter than F significantly(P<0.05),and the incidence of adverse events of group D was also lower than F(P<0.05).Conclusion Usual clinical doses of dezocine and fentanyl can prevent the incidence of agitation during recovery period after thoracic surgery effectively.However,the incidence of adverse events of dezocine is lower than fentanyl.

Key words: Piperidines/administration and dosage, Fentanyl, Thoracic Surgical Procedures