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S-100和CD83+DC在喉粘膜病变中的表达及意义

金丹1,王雪峰2   

  1. 1. 辽宁医学院附属第一医院耳鼻咽喉科咽喉病区
    2. 辽宁医学院附属第一医院耳鼻咽喉科
  • 收稿日期:2014-02-13 修回日期:2014-05-14 出版日期:2014-10-15 发布日期:2014-10-15
  • 通讯作者: 王雪峰

JIN Dan ,WANG Xue   

  1. Department of Otolaryngology, the First Affiliated Hospital of Liaoning Medical University,Jinzhou 121000,China
  • Received:2014-02-13 Revised:2014-05-14 Published:2014-10-15 Online:2014-10-15
  • Contact: WANG Xue

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摘要：

【摘要】目的 研究树突状细胞（DC）在声带息肉、喉黏膜白斑及声门型喉鳞癌组织中的表达差异。方法 采用免疫组化方法检测20 例声带息肉组织、47 例喉黏膜白斑组织、45 例声门型喉鳞癌组织及20 例正常喉黏膜组织中S-100+DC 及CD83+DC 的浸润情况。结果 声带息肉组、喉白斑组、声门型喉鳞癌组的S-100 及CD83+DC 数较正常喉黏膜组明显增多（P<0.05）；声带息肉组S-100 及CD83+DC 数比喉白斑组明显增多，声带息肉组及喉白斑组S- 100 及CD83+DC 数较声门型喉鳞癌组有所增加；在喉黏膜白斑组织中重度不典型增生组S-100 及CD83+DC 数明显高于轻、中度不典型增生组（P < 0.05）；高、中分化声门型喉鳞癌组S-100 及CD83+DC 数高于低分化组（P < 0.05）。结论 声带息肉、喉黏膜白斑及声门型喉鳞癌均存在免疫活动异常，DC 的变化在喉癌发生发展过程中发挥重要作用。

关键词: 喉粘膜白斑, 声门型喉鳞癌, 树突状细胞, S-100, CD83

Abstract:

[Abstract] Objective  To investigate the infiltration of dendritic cell (DC) in Vocal cord polyp, laryngeal leukopla? kia and glottic squamous cell carcinoma，and to observe laryngeal mucosal lesions of the state of the immune microenvironment, and to research significance of DC on the development of glottic squamous cell carcinoma. Methods  The infiltration of S-100+ and CD83+DC in 20 cases of Vocal cord polyp, 47 cases of laryngeal leukoplakia, 45 cases of glottic squamous cell carcinoma tumor and 20 cases of laryngeal normal mucosa were examined using immunohistochemistry. Results  The number of S-100+ and CD83+DC were significantly higher in glottic squamous cell carcinoma, laryngeal leukoplakia and vocal cord polyp than that in laryngeal normal mucosa (P < 0.05). The number of S-100+ and CD83+DC were higher in laryngeal leukoplakia than that in glottic squamous cell carcinoma (P < 0.05). The number of S-100+ and CD83+DC in mild dysplasia and moderate dysplasia were less than that in severe atypical hyperplasia (P < 0.01). In glottic squamous cell carcinoma, S- 100+ and CD83+ DC with poor-differentiated was significantly less than that with well-differentiated (P < 0.01). Conclusion  Changes in the number of dendritic cell was found in vocal cord polyp, laryngeal leukoplakia and glottic squamous cell carcinoma, which indicated that there were an abnormal immune status. Changing of dendritic cell in laryngeal mucosa plays an important role in laryngeal cancer development.

Key words: laryngeal leukoplakia, glottic squamous cell carcinoma, dendritic cells, S-100, CD83