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腺苷及其受体激动剂对不稳定心绞痛患者IL-18影响的研究

李永辉,张寰   

  1. 天津市第四中心医院心内科CCU
  • 收稿日期:2014-02-11 修回日期:2014-07-06 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 李永辉

Effects of Adenosine and the Selective Adenosine Receptor Agonist on the Expression of Interleukin-18 in Patient with Unstable Angina

LI Yong Hui,ZHANG Huan   

  1. Department of Cardiology, Fourth Central Hospital of Tianjin
  • Received:2014-02-11 Revised:2014-07-06 Published:2014-11-15 Online:2014-11-15
  • Contact: LI Yong Hui

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摘要：  【摘要】 目的 观察腺苷及腺苷受体激动剂对不稳定型心绞痛（UAP）患者白介素（IL）-18 的影响， 探讨腺苷受体的作用机制。 方法 选取 15 例 UAP 患者（UAP 组）及 15 例健康志愿者（对照组）， 采用腺苷及腺苷受体激动剂干预全血标本,双抗体夹心酶联免疫吸附法（ELISA）检测 IL-18。 结果 低浓度腺苷(1～ 100 μmol/L)对 UAP 组 IL-18表达有增强效应， 高浓度(1 mmol/L)有抑制效应。 腺苷 A1 受体激动剂与 A3 受体激动剂对 IL-18 表达有增强效应， 而腺苷 A2a受体激动剂对 IL-18 表达有抑制效应， 腺苷 A2b受体激动剂对 IL-18 表达未见明显效应。 结论 腺苷在低浓度时对 UAP 患者 IL-18 的表达有促进作用， 可能通过腺苷 A1 和 A3受体发挥效应；高浓度时有抑制作用， 可能通过腺苷 A2a受体发挥作用.

关键词: 心绞痛, 不稳定型, 白细胞介素 18, 腺苷, 受体, 腺苷 A1, 受体, 腺苷 A2

Abstract:

[Abstract]   Objective   To observe the effects of adenosine and adenosine receptor agonist on the expression of inter?leukin-18 (IL-18) in patients with unstable angina (UAP), and the mechanism of adenosine receptor agonists thereof.   Methods   Fifteen UAP and 15 healthy volunteers were included in this study. The effects of adenosine and the selective adenosine receptor agonists on the expression of IL-18 were measured by enzyme-linked immunosorbent assay (ELISA).   Results   The lower concentration of adenosine (1-100 μmol/L) increased the expression of IL-18 in UAP group; whereas the higher concentration of adenosine (1 mmol/L) inhibited the expression of IL-18. The adenosine A1 receptor agonist and A3 receptor agonist increased the expression of IL-18, while the adenosine A2a receptor agonist inhibited the expression of IL-18. There was no significant effect for A2b receptor agonist on the expression of IL-18.   Conclusion   The lower concentrations of ade?nosine can enhance the expression of IL-18 through adenosine A1 and A3 receptors in UAP. The higher concentrations of ade?nosine can inhibit the expression of IL- 18 through adenosine A2a receptors. Adenosine can promote IL- 18 expression in lower concentrations.

Key words: angina, unstable, interleukin-18, adenosine, receptor, adenosine A1, receptor, 腺苷 A2