天津医药

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肿瘤坏死因子α在多发性硬化及髓鞘再生中的研究进展

雷旭丹,徐菲,李玉皓   

  1. 南开大学医学院、天津市肿瘤微环境与神经血管调节重点实验室
  • 收稿日期:2014-05-21 修回日期:2014-07-14 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 李玉皓

The Research Progress of Tumor Necrosis Factor Alpha in Multiple Sclerosis and Remyelination

LEI Xu dan,XU Fei ,LI Yu hao   

  1. Key Laboratory of Tumor Microenviroment and Neurovascular Regulation, School of Medicine of Nankai University
  • Received:2014-05-21 Revised:2014-07-14 Published:2014-11-15 Online:2014-11-15
  • Contact: LI Yu hao

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摘要： 肿瘤坏死因子（TNF-α）是一种多向性细胞因子，存在可溶性和跨膜两种形式，分别结合肿瘤坏死因子受体1（TNFR1）和TNFR2来发挥功能。近年来研究发现，TNF-α/TNFR通路在多发性硬化的发生和髓鞘再生中发挥了重要作用。TNFR1通过死亡受体介导凋亡信号通路，导致少突胶质细胞及神经元的凋亡，从而引起髓鞘脱失等神经退行性改变。TNFR2通过一系列级联反应促进少突胶质细胞前体细胞的增殖以及分化，从而促进髓鞘的再生，在多发性硬化中有积极作用。

关键词: 肿瘤坏死因子α, 受体, 肿瘤坏死因子, 多发性硬化, 髓鞘, 髓鞘再生, 综述

Abstract:

[Abstract] Tumor necrosis factor (TNF)-α is a pleiotropic inflammatory cytokine, which is produced chiefly by acti?
vated macrophages. Two forms of TNF-α, soluble and transmembrane, can bind tumor necrosis factor receptor (TNFR) 1 orTNFR2, respectively. Recently, a concept has emerged that TNF-α/TNFR pathway plays an important role in the pathogenesis of multiple sclerosis and remyelination. TNFR1 induces death of oligodendrocytes via death receptor-mediated apoptosis, which leads to demyelination or other neurodegenerative changes. However, TNFR2 has a positive effect on multiple sclerosis. It facilitates the proliferation and differentiation of oligodendrocyte precursor cells, thus promoting remyelination.

Key words: tumor necrosis factor-alpha, receptors, tumor necrosis factor, multiple sclerosis, myelin sheath, remyelination, review