天津医药

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天津市中老年非高血压人群高同型半胱氨酸血症的影响因素分析

陈绘丽1,孙跃民1,王雪春1,司权1,姚薇2   

  1. 1. 天津医科大学总医院
    2. 天津医科大学总医院心内科
  • 收稿日期:2013-11-14 修回日期:2014-03-25 出版日期:2014-06-15 发布日期:2014-06-15
  • 通讯作者: 陈绘丽

  • Received:2013-11-14 Revised:2014-03-25 Published:2014-06-15 Online:2014-06-15
  • Contact: Hui-Li CHEN

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摘要： 调查天津市内6区中老年非高血压人群血浆同型半胱氨酸（homocysteine，Hcy）水平及高同型半胱氨酸血症（hyperhomocysteinemia，hHcy）的影响因素。方法 采用自然抽样方法，于2011年5月至2012年5月对天津市内6区40-70岁非高血压居民进行调查，问卷方式收集吸烟、饮酒、摄入蔬菜水果量等一般资料，循环酶法检测血浆Hcy；多因素Logistic回归分析hHcy（Hcy≥15μmol/L）的影响因素。结果 共入选874人（年龄57±6岁，男性25.5%），血浆Hcy水平为11.8μmol/L（男性14.1，女性11.1；P<0.001）。与饮食中蔬菜水果摄入量<250g/d的人群相比，摄入量>500g/d的人群有较低Hcy水平（P<0.05），在男性、P>0.05，在女性、P=0.037。男性与女性相比，hHcy的OR值为5.87（95%CI 3.29,10.44; P<0.001）；年龄为50-60岁、60-70岁与40-50岁相比，hHcy的OR值分别为2.31（95%CI 1.17,4.55; P=0.016）、3.39（95%CI 1.94,7.95; P<0.001）；饮食中蔬菜水果摄入量为250-500g/d、>500g/d与<250g/d相比，hHcy的OR值分别为0.71（95%CI 0.43,1.16; P=0.166）、0.50（95%CI 0.28,0.90; P=0.021）。结论 天津市市区中老年非高血压人群有升高的同型半胱氨酸水平，男性、年龄增加是高同型半胱氨酸血症的危险因素，摄入丰富的蔬菜水果是保护因素。

关键词: 同型半胱氨酸, 男性, 年龄, 蔬菜水果, 影响因素

Abstract: [Abstract] Objectives To estimated the concentration of homocysteine(Hcy) and determinants of hyperhomocysteinemia(hHcy,Hcy≥15μmol/L) among non-hypertensive people aged 40-70years in Tianjin. Methods The general characteristics of smoking, drinking, consumption of vegetable and fruits, et al were collected by means of questionnaire in the way of accident sample among community residents from May 2011 to May 2012. Plasma Hcy was measured by an enzyme cycling method. The determinants of having hHcy were evaluated from multivariate logistic regression models. Results 874 participants(mean age57±6years,male 25.5%) were involved in the survey and the concentration of Hcy was 11.8μmol/L(14.1 in male, 11.1 in female; P<0.001). The OR of having hHcy was 5.87(95%CI 3.29,10.44; P<0.001) in male, compared with female; 2.31(95%CI 1.17,4.55; P=0.016) and 3.39(95%CI 1.94,7.95; P<0.001) for participants aged 50-60 and 60-70, compared with 40-50years;0.71(95%CI 0.43,1.16; P=0.166) and 0.50(95%CI 0.28,0.90; P=0.021) for participants with consumption of vegetable and fruits >500g/d and 250-500g/d, compared with <250g/d. Conclusion The concentration of plasma homocysteine was elevated among non-hypertensive people in Tianjin. Male, increasing age were adverse factors of hyperhomocysteine, and volume of vegetable and fruits in diets was favorable one.

Key words: homocysteine, male, increasing age, consumption of vegetable and fruits, factors