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正常肾脏血氧依赖磁共振成像特点及与生理指标相关性研究

石会兰,郑振峰,马慧,李峰坦,张敬,张云亭   

  1. 天津医科大学总医院
  • 收稿日期:2013-10-14 修回日期:2013-12-17 出版日期:2014-06-15 发布日期:2014-06-15
  • 通讯作者: 石会兰

Blood oxygen level dependent magnetic resonance imaging of normal kidney and correlation with physiological indexes: A preliminary study

  • Received:2013-10-14 Revised:2013-12-17 Published:2014-06-15 Online:2014-06-15

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摘要： 目的 探索正常肾脏血氧水平依赖磁共振（BOLD-MRI）成像特点，以及与部分生理指标之间的相关性。方法 研究纳入90例行腹部磁共振检查的非肾脏病患者。血氧水平依赖磁共振成像扫描采用T2*自旋梯度回波（T2*SPGR）序列。BOLD-MRI影像分析采用R2*map后处理软件。分别从肾脏皮质和髓质区选取感兴趣区（ROI）测量表观自旋-自旋弛豫率(R2*)值。分析与患者年龄、性别、身高、体重、体重指数（BMI）、体表面积（BSA）和估算的肾小球滤过率（eGFR）之间的相关性。 结果 两侧肾脏皮质区R2*值均低于相应髓质区。女性和男性患者皮质R2*值也低于相应的髓质区。双侧肾脏髓质区，肾脏下极R2*值低于中极和上极，(F =15.184 , P <0.001)。年龄与髓质R2*值正相关(r =0.284, P =0.002). eGFR与髓质R2*值(r =-0.232, P =0.007)负相关。结论 BOLD-MRI可将血氧水平可视化。肾实质不同区域内氧含量水平存在差异。随年龄的增长和肾小球滤过率下降肾脏髓质氧含量水平下降。

关键词: 肾皮质, 肾髓质, 血氧水平依赖, 磁共振, R2*值

Abstract: Objective To explore the characteristics of blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) in healthy native kidneys. To investigate the relationship between BOLD-MRI and common physiological indexes. Methods Ninety patients who were ruled out chronic kidney diseases underwent BOLD-MRI with T2*-spoiled gradient recalled echo (T2*SPGR) sequence. BOLD images were analyzed on R2*map software to yield R2* pseudo-color map. Cortical and medullary R2* values were analyzed in bilateral kidneys and in different gender. Different regional R2* values in cortex and medulla were also analyzed. Physiological indices including age, body height and weight, body mass index (BMI), body surface area (BSA), estimated glomerular filtration rate (eGFR) was recorded. Correlation between R2* value and physiological indices were analyzed. Results Bilateral renal cortical R2* values were less than values in medulla. Female and male cortical R2* values were also less than corresponding values in medulla. In bilateral renal medullary region, R2* values in low pole was less than values in middle and upper pole (F =15.184 , P <0.001). Age positively correlated with R2* values in medulla(r =0.284, P =0.002). However, eGFR negatively correlated with medullary R2* value (r =-0.232, P =0.007). Conclusions BOLD MRI can directly visualize renal oxygenation. Oxygenation level discrepancy exists in different regions of renal parenchyma. In healthy kidneys, renal medullary oxygenation level attenuated when patient age increase and eGFR decrease.

Key words: renal cortex, renal medullar, blood oxygen level dependent, magnetic resonance, R2* value