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Runx2在乳腺癌中作用的研究进展

田垚   

  1. 天津医科大学
  • 收稿日期:2013-12-10 修回日期:2014-02-06 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 田垚

Role of Runx2in Breast Cancer

Yao TIAN   

  1. Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical UniversityTianjin 300060, China
  • Received:2013-12-10 Revised:2014-02-06 Published:2014-08-15 Online:2014-08-15
  • Contact: Yao TIAN

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摘要： 【摘要】  Runx2是转录因子RUNXX家族成员之一，作为参与乳腺组织中某些基因的表达调控的重要因子之一，在乳腺上皮细胞分化过程中发挥重要作用。本文就Runx2在乳腺癌中作用的研究进展综述如下。

关键词: 乳腺肿瘤, DNA结合蛋白质, 转录因子, 受体, 雌激素, 骨肿瘤, Runx2, 骨转移

Abstract: 【Abstract】  Runx2 is a member of the RUNXX family of transcription factors, as one of the important factors involved in expression and participation in the regulation of mammary specific genes in the mammary gland.In this review, we will focus on the role of Runx2 in breast cancer.

Key words: breast neoplasms, DNA- binding proteins, transcription factors, receptors, estrogen, bone neoplasms, Runx2, 骨转移