天津医药

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睡眠呼吸暂停模式间歇低氧对心脑血管的影响

韩苗苗1,何庆2,施遥3,冯靖4,陈宝元4   

  1. 1. 天津市西青医院
    2. 天津医科大学总医院内分泌科
    3. 天津市医科大学总医院
    4. 天津医科大学总医院
  • 收稿日期:2014-02-11 修回日期:2014-04-30 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 冯靖

the Effects of IH from OSA on Cardiovascular and Cerebrovascular Diseases

HAN Miaomiao 1,Qing HE2,SHI Yao 3,FENG Jing 4,CHEN Baoyuan 5   

  1. 1. Department of Endocrinology, Tianjin Xiqing Hospital, Tianjin 300380, China
    2. Tianjin Medical University General Hospital
    3. Department of Endocrinology
    4. Department of Respiratory Medicine,General Hospital of Tianjin Medical UniversityCorresponding Author E-mail:zyyhxkfj@126.com
    5. Department of Respiratory Medicine,General Hospital of Tianjin Medical University
  • Received:2014-02-11 Revised:2014-04-30 Published:2014-09-15 Online:2014-09-15
  • Contact: FENG Jing

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摘要： 阻塞性睡眠呼吸暂停（OSA）的特点是睡眠期间反复发生气道阻塞导致间歇性低氧（IH）、高碳酸血症、睡眠片段化和胸内压改变。其中，IH与高血压、动脉粥样硬化、冠心病、心律失常、脑卒中、心衰和猝死等病理生理过程相关。OSA模式下IH会导致代谢调节异常、内皮功能障碍、系统性炎性反应、氧化应激反应及神经体液的变化，可增加心血管疾病的风险。本文主要描述了目前对IH导致各种心血管疾病的发病机制的理解。

关键词: 睡眠呼吸暂停, 阻塞性, 缺氧, 高血压, 动脉粥样硬化, 冠心病, 心律失常, 心性

Abstract: Obstructive sleep apnea (OSA) is characterized by repeated intermittent hypoxia (IH), hypercapnia, sleep fragmentation and intrathoracic pressure change. The IH is related to hypertension, atherosclerosis, coronary heart disease, arrhythmia, stroke, heart failure and sudden death and so on. IH from OSA can lead to metabolic dysregulation, endothelial dysfunction, systemic inflammation, oxidative stress and the change of nerve body fluids, which has been shown to increase the risk of cardiovascular diseases. This paper mainly describes the pathogenesis of IH leading to the various cardiovascular diseases.

Key words: sleep apnea, obstructive, anoxia, hypertension, atherosclerosis, coronary disease, arrhythmias, 心性