天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (2): 179-182.doi: 10.11958/j.issn.0253-9896.2015.02.017

• 临床研究 • 上一篇    下一篇

PCSK9基因 rs11206510多态性与血脂及冠心病的关系

谭艳萍1 ,刘寅2△,高静2 ,孙根义2   

  1. 1天津医科大学研究生院 （邮编300070）； 2天津市胸科医院心内科
  • 收稿日期:2014-07-04 修回日期:2014-09-22 出版日期:2015-02-15 发布日期:2015-02-27
  • 通讯作者: 刘寅 E-mail:typ2015@yeah.net

Relationship between PCSK9 gene polymorphorism rs11206510 with blood lipid level and coronary heart disease

  • Received:2014-07-04 Revised:2014-09-22 Published:2015-02-15 Online:2015-02-27

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摘要： 摘要： 目的 探讨 PCSK9 rs11206510 基因多态性与脂代谢及发生冠心病 （CHD） 风险的相关研究。方法 选择在天津市胸科医院住院患者 778 例， 分为 CHD 组 502 例和对照组 276 例。入院后检验三酰甘油(TG)、 高密度脂蛋白胆固醇 （HDL-C）、 低密度脂蛋白胆固醇 （LDL-C）、 载脂蛋白(Apo)A1、 ApoB 并检测入选人群的基因型 TT、 TC、 CC。结果 CHD 组 TC 基因型组 LDL-C 水平较 TT 基因型组高 （P＜0.05）。CHD 组和对照组均以 TT 基因型为主， 2 组基因型频率分布和等位基因频率分布差异均无统计学意义 （P＞0.05）。被检总人群等位基因频率分别为 T 96.1% (1 495/1 556)， C 3.9%(61/1 556)； 基因型频率分别为 TT 92.2%(717/778)， TC 7.8%(61/778)。多因素 Logistic 回归分析 ApoA1、 HDL-C 是 CHD 的保护因素。结论 CHD 组 TC 基因型与血清 LDL-C 的升高有相关性， 而等位基因 C 与 CHD 的发病无明显相关性。

关键词: 冠心病； 多态现象, 遗传； 载脂蛋白类； 脂蛋白类； PCSK9

Abstract: Abstract： Objective To investigate the relationship between PCSK9 gene polymorphism with lipid metabolism and CHD risk among population within Tianjin, China. Methods Patients from Tianjin Chest Hospital were selected (n=778) and divided into coronary heart disease (CHD) group (n=502) and control group (n=276). Immediately after admission, tri⁃ glyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A (ApoA1) and apolipo⁃ protein B (ApoB) were tested and genotype TT,TC and CC were determined. Results In CHD group, LDL-C level is higher in TC genotype individuals than that in TT genotype individuals with statistical significance (P＜0.05). CHD group and the control group were dominated by TT genotype with no statistical difference between their allele frequency distribution nor genotype frequency distribution(P ＞ 0.05). The total population allele frequencies were T 96.1% (1 495/1 556), C 3.9% (61/ 1 556); genotype frequencies were TT 92.2% (717/778), TC 7.8% (61/778). Multivariate Logistic regression analysis revealed that ApoA1 and HDL-C were inversely associated with coronary heart disease, therefore are protective factors for coronary heart disease. Conclusion The study found that TC genotype is correlated with serum LDL-C increase in group CHD, and the incidence of allele C showed no obvious connection with CHD.

Key words: coronary disease, polymorphism, genetic, apolipoproteins, lipoproteins, PCSK9