关键词: 高原, 藏族人群, 坎地沙坦, 慢性收缩性心力衰竭

Abstract: Objective The treatment effect of chronic systolic heart failure with Candesartan in plateau Tibetan nationality is discussed in this paper. Method Cases studied consist of 526 individuals with chronic systolic heart failure, which are divided into two groups randomly (i.e., control group with 252 cases and reference group with 274cases). Routine medicine is given to individuals in both groups on the basement of protopathy treatment, such as cardiac, diuretic and vasodilator drugs. Additionally, enalapril is used in reference group, while candesartan in control group. Comparison of the improvement of cardiac function, LVEF, LVEDD and blood pressure between two groups is also conducted after 8 weeks. Results There was no significant difference between treatment and control groups for effective rate (i.e., 45.2% in treatment group and 44.9% in control group, respectively), efficiency rate (i.e., 54.8% in treatment group and 55.1% in control group, respectively) and Inefficiency (i.e., 2.0% in treatment group and 2.2% in control group, respectively). After treatment, LVEF in the two groups are all improved, while LVEDD and blood pressure decreased, and statistical significance are also found. However, the difference between the two groups is not significant. Conclusion No statistical difference was found for the treatment of chronic systolic heart failure in Plateau Tibetan in the 2 groups, and candesartan seems more effective than enalapril.

Key words: plateau, Tibetan, candesartan, chronic systolic heart failure