天津医药 ›› 2016, Vol. 44 ›› Issue (1): 124-126.doi: 10.11958/58828

• 综述 • 上一篇    下一篇

母亲肥胖对后代的影响

段洋1 , 孙夫强1 , 刘戈力2△   

  1. 1天津医科大学第二医院新生儿科 (邮编300211); 2天津医科大学总医院儿科
  • 收稿日期:2015-04-21 修回日期:2015-07-30 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: △审校者 E-mail: liugeli2001@126.com E-mail:yangguang100521@163.com
  • 作者简介:段洋 (1981), 女, 主治医师, 硕士, 主要从事新生儿脑损伤、 新生儿内分泌遗传代谢性疾病研究

Effects of maternal obesity on the offspring

DUAN Yang1 , SUN Fuqiang1 , LIU Geli 2△   

  1. 1 Department of Neonatology, Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2 Department of Pediatrics, Tianjin Medical University General Hospital
  • Received:2015-04-21 Revised:2015-07-30 Published:2016-01-15 Online:2016-01-15
  • Contact: △Revisor E-mail: liugeli2001@126.com E-mail:yangguang100521@163.com

摘要: 摘要: 近年来母亲肥胖发病率明显增加, 母亲肥胖可导致慢性炎症、 氧化应激、 细胞因子内稳态的改变, 增加妊娠不良结局的危险。怀孕前和怀孕过程中母亲肥胖的代谢状态能够改变胎盘 DNA 甲基化水平, 且会引起胎儿 “程序化” 改变, 影响妊娠结局, 增加后代发生肥胖相关的代谢综合征等慢性病风险。积极预防和干预母亲肥胖, 可降低不良妊娠结局, 提高后代生存质量。

关键词: 母亲, 肥胖症, 胎儿, 代谢综合征, 后代, 影响, 综述

Abstract: Abstract:The prevalence of maternal obesity has risen dramatically in recent years. Maternal obesity increases the risk of adverse pregnancy outcomes, and can lead to chronic inflammation, oxidative stress, the change of cell factor homeostasis. The metabolic status of maternal obesity in the pre-pregnancy and pregnancy can alter the level of DNA methylation in the placenta, change the fetal programming, influence the pregnancy outcomes, and increase the risk of obesity related metabolic syndrome and other chronic diseases of offspring. Actively preventing and intervening in the maternal obesity can reduce the adverse pregnancy outcomes and increase the survival quality of the offspring.

Key words: mothers, obesity, fetus, metabolic syndromes, offspring, influence, review