天津医药 ›› 2016, Vol. 44 ›› Issue (1): 26-29.doi: 10.11958/59009

• 专题研究呼吸系统疾病 • 上一篇    下一篇

胸腔和呼出气氧和二氧化碳分压测定对气胸脏层胸膜破口闭合的预测价值

贾玮, 李海娜, 李月川△, 张冬睿, 谷松涛, 张永祥, 马晖   

  1. 天津市胸科医院呼吸与危重症医学科 (邮编300222)
  • 收稿日期:2015-05-29 修回日期:2015-10-27 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: △通讯作者 E-mail: liyuechuandoctor@126.com E-mail:liyuechuandoctor@126.com
  • 作者简介:贾玮 (1972), 女, 副主任医师, 硕士, 主要从事胸膜腔疾病、 肺血管疾病、 呼吸介入治疗方面研究
  • 基金资助:
    基金项目: 天津市卫生行业重点攻关项目 (13KG132)

Clinical value of gas partial pressure evaluation to the closure of visceral pleura in pneumothroax patients

JIA Wei, LI Haina, LI Yuechuan△, ZHANG Dongrui, GU Songtao, ZHANG Yongxiang, MA Hui   

  1. Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin 300222, China
  • Received:2015-05-29 Revised:2015-10-27 Published:2016-01-15 Online:2016-01-15
  • Contact: △Corresponding Author E-mail:liyuechuandoctor@126.com E-mail:liyuechuandoctor@126.com

摘要: 摘要:目的 探讨胸腔和呼出气体氧分压[p (O2 ) ]及二氧化碳分压[p (CO2 ) ]对自发性特发性气胸 (PSP) 患者脏层胸膜破口闭合判断的预测价值。方法 确诊为 PSP 的患者 76 例, 根据胸部 X 线片观察肺复张情况作为判定脏层胸膜破口是否闭合的金标准进行分组, 其中闭合组 40 例, 开放组 36 例。利用自行研制的呼出气采集器采集患者的呼气末气体, 通过胸腔穿刺收集胸腔气体, 同时采集桡动脉血, 分别测定呼出、 动脉血及胸腔气中的 p (O2 ) 和 p (CO2 ), 并进行相关数据分析。结果 闭合组胸腔气p (O2 ) 低于开放组, p (CO2 ) 高于开放组 (P<0.05); 2组呼出气和动脉血p (O2 )和 p (CO2 ) 差异均无统计学意义 (P>0.05); 闭合组的呼出气/胸腔气 p (O2 ) 比值高于开放组, p (CO2 ) 比值低于开放组(P<0.05); 二分类 Logistic 回归分析显示, 呼出气/胸腔气 p (O2 ) 和 p (CO2 ) 比值为 PSP 脏层胸膜破口闭合的影响因素; ROC曲线分析显示, 呼出气/胸腔气p (O2 ) 的ROC曲线下面积为0.985, 敏感度和特异度分别为92.5%和100%, 最佳参考值为1.81; 呼出气/胸腔气p (CO2 ) 的ROC 曲线下面积为0.867, 敏感度和特异度分别为77.8%和85.0%, 最佳参考值为0.97。结论 测定胸腔气体和呼出气体p (O2 ) 和p (CO2 ) 对判断PSP患者脏层胸膜破口是否闭合具有预测价值。

关键词: 早期诊断; , 敏感性与特异性;, 脏层胸膜; , 闭合; , 开放; , 氧分压;, 二氧化碳分压; , 自发性特发性气胸

Abstract: Abstract: Objective To study the predictive value of evaluation in oxygen partial pressure[p(O2)] and carbon dioxide partial pressure[p(CO2)] of pleural cavity to the closure of visceral pleura in primary spontaneous pneumothroax (PSP) pa⁃ tients. Methods Seventy-six hospitalized pneumothroax patients were divided into two groups: closed pneumothroax group (n=40) and open pneumothroax group (n=36), according to the radiographic information.To collect the expiratory gas by the device which we designed and produced, to collect the gas in the pleural cavity by thoracentesis. To detect the p (O2 )and p (CO2 )respectively, and the blood gas analysis of radial artery was done at same time. Results There was significantly low⁃ er value of p(O2 )of the gas in the pleural cavity in patients of closed pneumothroax than that of open pneumothroax (P < 0.05). The level of p (CO2 ) was higher in patients of closed pneumothroax than that of open pneumothroax ( P < 0.05). There were no significant differences in values of p (O2 ) and p (CO2 ) in expiratory gas and the blood gas analysis between two groups (P>0.05). There was significantly higher value of the expiratory gas / the pleural cavity gas p(O2) and a significantly lower value of p(CO2), in closed pneumothroax group than those of open pneumothroax group (P < 0.05). Logistic regression analy⁃ sis showed that values of the expiratory gas / the pleural cavity gas p(O2) and p(CO2) were the effective factors for the closure of visceral pleura. ROC curve showed that the areas under ROC curve (AUC) for the expiratory gas/the pleural cavity gas p(O2) and p(CO2) was 0.985 and 0.867, the sensitivities were 92.5% and 77.8%, the specificities were 100% and 85.0% and the reference values were 1.81 and 0.97. Conclusion To utilize the evaluation of gas partial pressure can predict whether the leakage of the visceral pleura is closed.

Key words: early diagnosis ;, sensitivity and specificity;visceral pleura, closure, open, oxygen partial pressure;, crbon dioxide partial pressure;, primary spontaneous pneumothorax