天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (1): 104-108.doi: 10.11958/20160855

• 综述 • 上一篇    下一篇

FBLN-5 在肿瘤形成中作用的研究进展

安冬 1， 杨军红 1△， 宋晓萌 2   

  1. 1. 天津市儿童医院
    2. 天津医科大学
  • 收稿日期:2016-08-19 修回日期:2016-11-16 出版日期:2017-01-15 发布日期:2017-01-15
  • 通讯作者: 杨军红 E-mail:nijikazuy@163.com
  • 基金资助:
    国家自然科学基金

Research progress of FBLN-5 in the role of tumorigensis

AN Dong1, YANG Jun-hong1△, SONG Xiao-meng2   

  1. 1 Department of Nutrition, Tianjin Children’ s Hospital, Tianjin 300134, China; 2 Tianjin Medical University
  • Received:2016-08-19 Revised:2016-11-16 Published:2017-01-15 Online:2017-01-15

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摘要： 摘要： Fibulin 蛋白家族广泛存在于细胞外基质， 对基底膜的形成、 维持以及弹性纤维和疏松结缔组织的稳定都 有着重要作用。Fibulin-5 （FBLN-5） 是 Fibulin 蛋白家族成员之一， 在细胞的结构组成以及信号介导等方面都不可或 缺， 其缺失能够引起如内脏器官畸形等多种疾病的发生。目前研究认为， FBLN-5 表达水平的变化与肺癌等多种肿 瘤的发生相关， 并能够影响肿瘤的增殖、 侵袭及预后进展， 因此有可能成为肿瘤诊断新的分子标志物。本文对 FBLN-5 的生物学特性与功能及其在肿瘤发生发展中的作用机制进行综述。

关键词: FBLN-5, 整合素, 肿瘤血管形成, 上皮-间质转化

Abstract: Abstract：Fibulin protein family has widely existed in the extracellular matrix, and plays an important role in maintain the stable of basement membrane, elastic fibers and loose connective tissue. Fibulin-5 (FBLN-5) is one of the members of the Fibulin protein family, which is essential to the structure function and cell mediated action. The lack of FBLN- 5 will cause many diseases such as internal organ deformity. Current research suggests that changes of expression level of FBLN-5 are associated with the occurrence of tumors such as lung cancer, and also can influence the tumor proliferation, invasion and prognosis, thus may become a new molecular marker for cancer diagnosis. Therefore, in this review, we summarize and update biological characteristics and functions of FBLN-5, and its role in the development of tumor formation mechanism.

Key words: FBLN-5, Integrin, Tumor angiogenesis, EMT