天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (7): 726-729.doi: 10.11958/20170053

• 临床研究 • 上一篇    下一篇

不同剂量鱼精蛋白中和肝素对体外循环辅助下冠状动脉旁路移植术围术期的影响

田莹 ，焦晶雪，刘旭伟，韩珊珊 ，王维铁   

  1. 1 吉林大学第二医院麻醉科手术室 （邮编 130041）；2 天津市第一中心医院心血管外科
  • 收稿日期:2017-01-11 修回日期:2017-06-14 出版日期:2017-07-15 发布日期:2017-08-08

The influence of different dosage of protamine neutralization heparin on perioperation of on-pump coronary artery bypass grafting

TIAN Ying,JIAO Jing-xue,LIU Xu-wei,HAN Shan-shan,WANG Wei-tie   

  1. 1 Department of Anaesthesia and Operating, the Second Hospital of Jilin University, Changchun 130041, China;2 Department of Cardiovascular Surgery, Tianjin First Central Hospital
  • Received:2017-01-11 Revised:2017-06-14 Published:2017-07-15 Online:2017-08-08

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摘要： 目的 探讨不同剂量鱼精蛋白中和肝素对体外循环辅助下冠状动脉旁路移植术（CABG）围术期的影响。方法 选取 2015 年 1 月—2016 年 11 月收治的 180 例体外循环下 CABG 患者， 随机分为鱼精蛋白 1~3 组， 每组 60例。体外循环开始前给予 3 mg/kg 肝素， 心内手术结束以后， 鱼精蛋白 1 组用鱼精蛋白中和肝素后使活化凝血时间（ACT） 高于插管前 ACT 的 10%， 鱼精蛋白 2 组中和至使 ACT 与插管前相当， 鱼精蛋白 3 组中和至使 ACT 低于插管前 10%。比较 3 组术中及术后相关指标的差异。结果 3 组患者住院期间无死亡。相比 1 组和 2 组， 鱼精蛋白 3 组的手术时间、 出手术室前 ACT、 返回 ICU 1 h 后 ACT、 术中出血量、 关胸时间和术中红细胞输注量减少， 鱼精蛋白总量和鱼精蛋白与肝素比值升高 （均 P < 0.05）。3 组术后心功能不全、 围术期心肌梗死、 肺水肿、 肺部感染、 肾功能不全、伤口愈合不良、 神经系统并发症、 住院时间等指标比较差异无统计学意义（P＞0.05）。结论 鱼精蛋白中和肝素使ACT 达到术前 ACT 的 90%较为安全， 能明显减少出血量， 缩短关胸时间及红细胞输注量， 有一定的临床意义。

关键词: 鱼精蛋白类, 冠状动脉旁路移植术, 体外循环, 肝素, 手术后并发症, 活化凝血时间

Abstract: Objective To investigate the effect of different doses of protamine neutralizing heparin on perioperation of on-pump coronary artery bypass graftting (CABG). Methods A total of 180 on-pump CABG patients hospitalized from January 2015 to November 2016 were randomly divided into three groups, the protamine group 1, protamine group 2 and protamine group 3, 60 patients in each group. Heparin (3 mg/kg) was used before extracorporeal circulation. After intracardiac operation was over, protamine was used to neutralize the heparin to adjust the activated clotting time (ACT) in protamine group 1, which was 10% higher than that of intubation. Meanwhile, protamine group 2 was neutralized to equal to the ACT before intubation, and protamine group 3 was 10% lower than that before the intubation. The differences of intraoperative and postoperative parameters were compared between the three groups. Results No death was found in the three groups during hospitalization. Comparing with protamine group 1 and protamine group 2, the time of operation, the ACT before the leaving operation room, the ACT of the first hour after returning to ICU, the amount of bleeding during operation, the time of closing and the amount of red blood for transfusion were decreased in protamine group 3 (P＞0.05).The total amount of protamine for neutralizing and the ratio of protamine and heparin were significantly increased in protamine group 3 (P＜0.05). The heart dysfunction after operation, perioperative myocardial infarction, pulmonary edema,pulmonary infection, renal dysfunction, poor wound healing, neurological complications, and time of in hospital stay showed no significant differences between three groups (P＞0.05). Conclusion ACT below 10% of preoperation is safe, after neutralization of heparin by protamine, which can obviously reduce the bleeding, the time of sternal closure and the amount of red blood cell transfusion, showing a positive clinical significance.

Key words: protamines, coronary artery bypass graftting, extracorporeal circulation, heparin, postoperative complications, activated clotting time

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