天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (6): 657-660.doi: 10.11958/20180135

• 综述 • 上一篇    下一篇

基质相互作用蛋白分子1在肿瘤发生发展和 临床应用中的研究进展

胡金萌，王健   

  1. 天津医科大学肿瘤医院，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心（邮 编300060）
  • 收稿日期:2018-01-22 修回日期:2018-03-22 出版日期:2018-06-15 发布日期:2018-07-05
  • 通讯作者: 胡金萌 E-mail:hujinmeng11@sina.com

Research progress of STIM1 in tumor development and clinical application

HU Jin-meng, WANG Jian   

  1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
  • Received:2018-01-22 Revised:2018-03-22 Published:2018-06-15 Online:2018-07-05
  • Contact: HU JINMENG E-mail:hujinmeng11@sina.com

PDF (PC)

3565

摘要： 基质相互作用蛋白分子1（STIM1）与肿瘤的发生发展密切相关，其参与多种癌症细胞凋亡、增殖、迁移和侵袭的调节过程。阻断或敲除STIM1可以显著抑制癌细胞的增殖和迁移。阐明STIM1在癌症细胞中的调节机制，将有助于新的治疗靶点的确定。本文对STIM1分子在不同肿瘤中的作用机制及临床应用前景作一综述。

关键词: 基质相互作用蛋白分子 1, 钙离子, 钙池操纵性钙通道, 钙池操纵性钙内流, 钙释放激活钙通道, Orai蛋白

Abstract: Studies have shown that stromal interaction molecule 1(STIM1) is closely related to the development of tumors, and which is involved in the regulation of apoptosis, proliferation, migration and invasion in many human cancers.Blocking or knockdown of STIM1 can significantly inhibit the proliferation and migration of cancer cells. Elucidation of the regulatory mechanism of STIM1 in cancer cells will be helpful for the identification of new therapeutic targets. This paper reviews the mechanism of STIM1 molecule in different tumors and its clinical application.

Key words: stromal interaction molecule1, calcium, store-operated calcium channels, store-operated calcium entry, Calcium release-activated calcium channels, Orai