天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (9): 1013-1018.doi: 10.11958/20180113

• 综述 • 上一篇    下一篇

缺乏维生素D受体激活及CYP27B1代谢调控在心肾综合征中的作用

王蕾，孙凤姣，李旭   

  1. 天津市医药科学研究所心脑血管药物研发中心（邮编300020）
  • 收稿日期:2018-01-19 修回日期:2018-04-20 出版日期:2018-09-15 发布日期:2018-10-10
  • 通讯作者: 王蕾 E-mail:zws9905@sina.com

vitamin D| calcitriol| receptors, calcitriol| CYP27B1| cardiorenal syndrome

WANG Lei,SUN Feng-jiao,LI Xu   

  1. Cardiovascular and Cerebrovascular Drugs Research and Development Center, Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China
  • Received:2018-01-19 Revised:2018-04-20 Published:2018-09-15 Online:2018-10-10

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摘要： 近年来研究发现，缺乏维生素D受体（VDR）激活与心肾综合征的发生发展关系密切。循环血液中90%以上的活性维生素D，即1，25（OH）2D3必须经由肾脏25-羟基维生素D-1α-羟化酶（CYP27B1）的羟化作用产生，从而发挥生物学效应。心肾综合征时，CYP27B1酶受损，循环内分泌1，25（OH）2D3生成不足，其与心脏和肾脏VDR结合减少，从而加重心肾损伤。因此，CYP27B1和VDR可能成为联系肾脏病和心血管疾病的重要靶标。本文就维生素D/VDR和CYP27B1的代谢调控在心肾综合征中的作用进行综述，以期为心肾综合征的治疗提供新的思路。

关键词: 维生素D, 骨化三醇, 受体, 骨化三醇, 25-羟基维生素D-1α-羟化酶, 心肾综合征

Abstract: In recent years, it has been found that the lack of vitamin D receptor (VDR) activation is closely associated with the development of cardiorenal syndrome (CRS). Hydroxylation catalyzed by renal 25-hydroxyvitamin D-1α hydroxylase(CYP27B1) is responsible for over 90% circulating concentrations of vitamin D activation, which then exerts biologic actions of vitamin D. Loss of renal CYP27B1 during CRS is associated with gradual decline in circulating 1,25(OH)2D3, resulting in inadequate VDR activation in renal and cardiac tissues, thereby promoting renal and cardiac damages. Therefore, CYP27B1 and VDR may become key targets for the combination of chronic kidney disease and cardiovascular disease. In this paper,the roles of vitamin D / VDR and metabolic regulation of CYP27B1 in CRS are reviewed, which may also provide new therapeutic strategies for CRS.

Key words: vitamin D, calcitriol, receptors, calcitriol, CYP27B1, cardiorenal syndrome