天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (2): 220-224.doi: 10.11958/20181245

• 综述 • 上一篇    

发热伴血小板减少综合征及其病原学研究进展

汪静杰1 ， 刘志新1 ， 位秀丽1 ， 杨靖1， 2 ， 李健1， 2 ， 谭华炳2 ， 刘龙1， 2△   

  1. 1湖北医药学院基础医学院 （邮编442000）； 2湖北医药学院附属人民医院感染性疾病科
  • 收稿日期:2018-08-20 修回日期:2018-11-28 出版日期:2019-02-15 发布日期:2019-02-15
  • 通讯作者: 刘龙 E-mail:499069851@QQ.COM
  • 基金资助:
    十堰市科技局项目;湖北医药学院人才启动金项目

Research progress of severe fever with thrombocytopenia syndrome and its etiology

WANG Jing-jie1 , LIU Zhi-xin1 , WEI xiu-li 1 , YANG Jing1,2 , LI Jian1,2 , TAN Hua-bing2 , LIU Long1,2△   

  1. 1 School of Basic Medical Sciences, 2 Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China
  • Received:2018-08-20 Revised:2018-11-28 Published:2019-02-15 Online:2019-02-15

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摘要： 发热伴血小板减少综合征病毒 （SFTSV） 是一种新发现的RNA病毒， 属于布尼亚病毒科， 是发热伴血小板 减少综合征 （SFTS） 的致病病原。SFTSV主要出现在中国中部和东部省份的农村地区和丘陵地带， 目前已造成严重 的公共卫生问题。SFTS主要有发热、 呕吐、 外周血血小板减少、 肝肾功能受损等症状， 部分患者因多器官功能衰竭而 死亡， 致死率达10%~15%。本文从SFTSV病原学、 感染过程、 致病机制、 流行病学特点、 临床诊断及检测方法等方面 对相关研究进行综述， 并提出存在的问题及防控措施， 为该病的诊断和防控提供参考。

关键词: 血小板减少, 疾病传播, 水平, 诊断, 白蛉病毒, 检测

Abstract: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly discovered RNA virus belonging to the family Bunyaviridae, which has been identified as the causative agent of severe fever with thrombocytopenia syndrome (SFTS). SFTSV mainly appears in rural and hilly areas in central and eastern provinces of China, and has caused serious public health problems. SFTS presents mainly have symptoms including fever, vomiting, peripheral blood thrombocytopenia, liver and kidney function damage. Some patients died due to multiple organ dysfunction, and the mortality rate has reached to 10%-15%. This review focused on the research progress in the etiology, infection process, pathogenesis, epidemiology, clinical diagnosis and detection methods of SFTSV, and put forward the existing problems and preventive measures to provide a reference for the diagnosis, prevention and control of this disease.

Key words: thrombocytopenia, disease transmission, horizontal, diagnosis, phlebovirus, detection