天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (5): 548-551.doi: 10.11958/20212271

• 药物临床观察 • 上一篇    下一篇

亲环素A在GDM中的表达及其与氧化应激、炎症反应和妊娠结局的关系研究

朱荣英1，朱艳芳2，习静3   

  1. 1甘肃医学院附属医院产科（邮编744000）；2兰州大学病理学研究所；3甘肃医学院附属医院检验科
  • 收稿日期:2021-10-09 修回日期:2021-12-21 出版日期:2022-05-15 发布日期:2022-07-04

The expression of cyclophile A in gestational diabetes and its relationship with oxidative stress, inflammation and pregnancy outcome outcome

ZHU Rongying1, ZHU Yanfang2, XI Jing3   

  1. 1 Department of Obstetrics, the Affiliated Hospital of Gansu Medical College, Pingliang 744000, China; 2 Institute of Pathology, Lanzhou University; 3 Department of Laboratory, the Affiliated Hospital of Gansu Medical College 
  • Received:2021-10-09 Revised:2021-12-21 Published:2022-05-15 Online:2022-07-04

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摘要： 目的　探讨亲环素A（Cyp A）在妊娠期糖尿病（GDM）中的表达及其与氧化应激、炎症反应和妊娠结局的关系。方法　选取GDM患者96例作为GDM组，另选取孕检的正常妊娠女性40例作为对照组。另据GDM患者的妊娠结局将其分为不良妊娠组（39例）和正常妊娠组（57例）。根据GDM患者的血清Cyp A中位数水平分为高表达组（Cyp A＞5.26 mg/L）47例和低表达组（Cyp A≤5.26 mg/L）49例。硫代巴比妥酸比色法检测血清丙二醛（MDA）的水平，黄嘌呤氧化酶法检测血清超氧化物歧化酶（SOD）的水平，酶联免疫吸附试验检测血清8-异前列腺素F2α（8-iso-PGF2α）、白细胞介素（IL）-6、超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）以及Cyp A的水平。结果　与对照组比较，GDM组Cyp A、MDA、8-iso-PGF2α、IL-6、hs-CRP、TNF-α、FBG、HbA1c水平升高，SOD水平降低（P＜0.05）。与正常妊娠组比较，不良妊娠组Cyp A、MDA、8-iso-PGF2α、IL-6、hs-CRP、TNF-α、FBG、HbA1c水平升高，SOD水平降低（P＜0.05）。GDM患者的血清Cyp A表达水平与FBG、HbA1c、MDA、8-iso-PGF2α、IL-6、hs-CRP、TNF-α均呈正相关，与SOD呈负相关（P＜0.05）。与低表达组比较，高表达组巨大儿、子痫前期发生率较高（P＜0.05）。结论　Cyp A在GDM患者血清中呈异常高表达，且与患者的氧化应激、炎症反应和妊娠结局关系密切。

关键词: 糖尿病, 妊娠；亲环素A；氧化性应激；炎症；妊娠结局

Abstract: Abstract: Objective To investigate the expression of cyclophile A (Cyp A) in Gestational diabetes mellitus (GDM) and its relationship with oxidative stress, inflammation and pregnancy outcome..Methods 98 GDM patients admitted to our hospital from January 2019 to December 2020 were selected as the study group, and 40 normal pregnant women who had a pregnancy examination in our hospital during the same period were selected as the control group.According to the adverse pregnancy outcome of GDM patients, it was divided into adverse pregnancy outcome group and normal pregnancy outcome group. According to the serum CYP a level of GDM patients, it was divided into high expression group and low expression group.Serum CYP A, oxidative stress index[malondialdehyde (MDA),superoxide dismutase (SOD),8-iso-prostaglandin F2α (8-iso-PGF2α)] and inflammatory factors [interleukin-6(IL-6),High-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-ɑ (TNF-ɑ)]of all subjects were detected, and the incidence of adverse pregnancy outcomes of all GDM patients was counted.Results The levels of Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), MDA, 8-iso-PGF2α, IL-6, hs-CRP, TNF-ɑ, and Cyp A in the study group were higher than those in the control group, and the SOD level was lower than the control group (P<0.05);The levels of FBG, HbA1c, MDA, 8-iso-PGF2α, IL-6, hs-CRP, TNF-ɑ, and Cyp A in the adverse pregnancy outcome group were higher than those in the normal pregnancy outcome group, and SOD levels were lower than the normal pregnancy outcome group (P<0.05);The incidence of macrosomia and preeclampsia in the high expression group was higher than that in the low expression group, and the difference was statistically significant (P<0.05); the incidence of neonatal hypoglycemia, premature rupture of membranes, placental abruption, and preterm delivery in the high expression group All were higher than the low expression group, but the difference was not statistically significant (P>0.05).The serum Cyp A expression level of GDM patients was positively correlated with FBG, HbA1c, MDA, 8-iso-PGF2α, IL-6, hs-CRP, and TNF-ɑ, and negatively correlated with SOD (P<0.05).Conclusion Cyp A is abnormally highly expressed in the serum of patients with GDM, and is closely related to the patient’s oxidative stress, inflammatory response and pregnancy outcome.

Key words: diabetes, gestational, cyclophilin A, oxidative stress, inflammation, pregnancy outcome

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