天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (6): 665-669.doi: 10.11958/20171441

• 综述 • 上一篇    下一篇

性激素对药物诱发的长QT综合征离子通道的作用

王翠华，贾心乐，刘衍恭，郑明奇   

  1. 1河北医科大学第一医院心脏中心（邮编050031）；2日本大分大学病态生理研究室
  • 收稿日期:2017-12-13 修回日期:2018-03-18 出版日期:2018-06-15 发布日期:2018-07-05
  • 通讯作者: 郑明奇 E-mail:mzheng2020@163.com

The role of sex hormones on ion channels of drug-induced long QT syndromes

WANG Cui-hua, JIA Xin-le, LIU Yan-gong, ZHENG Ming-qi   

  1. 1 Department of Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China; 2 Department of Pathophysiology, Oita University School of Medicine, Japan
  • Received:2017-12-13 Revised:2018-03-18 Published:2018-06-15 Online:2018-07-05
  • Contact: ZHENG Mingqi E-mail:mzheng2020@163.com

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摘要： 无论在先天性长 QT 综合征（LQTs），还是获得性长 QT 综合征，女性性别都是尖端扭转型室性心动过速（TdP）发展的独立危险因素。研究表明性激素可能影响心肌复极电流，从而影响心肌复极的性别差异。本文综述了性激素对心脏离子通道电流的影响，以及对药物诱发的长QT综合征性别差异的影响，并用计算机模拟的方法阐明性激素诱发心律失常的机制。

关键词: 性腺甾类激素, 心律失常, 心性, 性别因素, 心肌复极, 综述

Abstract: Female gender is an independent risk factor for the development of torsade de pointes (TdP) arrhythmias not only in congenital long QT syndromes（LQTs）but also in acquired long QT syndromes. Clinical evidences imply that sex steroid hormones appear to play important roles in gender differences by affecting the cardiac repolarization process of action potential. This review summarizes the effects of sex hormones on cardiac ion channel currents and the effects of gender differences on drug-induced long QT syndromes, and reveals the mechanism of sex hormone induced arrhythmia by computer simulation

Key words: gonadal steroid hormones, arrhythmias, cardiac, sex factors, myocardial repolarization, review