天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (6): 656-662.doi: 10.11958/20203050

• 综述 • 上一篇    下一篇

NLRP3炎性体在心肌缺血再灌注损伤中作用的研究进展 #br#

李丹，高珊
  

  1. 1天津中医药大学第一附属医院（邮编300381）；2天津市中医方证转化研究重点实验室
  • 收稿日期:2020-11-05 修回日期:2021-02-01 出版日期:2021-06-15 发布日期:2021-06-15
  • 通讯作者: 高珊 E-mail:tinaxiaojuan8911@126.com
  • 基金资助:
    国家自然科学基金;天津市教委科研计划项目;天津市卫生和计划生育委员会中医、中西医结合科研专项课题

Research progress on the role of NLRP3 inflammasome in myocardial ischemia-reperfusion injury #br#

LI Dan, GAO Shan#br#   

  1. 1 The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China; 2 Tianjin Key
    Laboratory of Translational Research of TCM Prescription and Syndrome
  • Received:2020-11-05 Revised:2021-02-01 Published:2021-06-15 Online:2021-06-15

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摘要： 炎性体是一种大分子多蛋白复合体，是固有免疫的重要组成成分。核苷酸结合寡聚化结构域受体蛋白3（NLRP3）炎性体是目前被研究得最多的炎性体。NLRP3炎性体由NLRP3、凋亡相关斑点样蛋白（ASC）及pro-半胱氨酸天冬氨酸特异性蛋白酶（caspase）-1组成。当细胞受到刺激时，NLRP3被激活并能够通过结合蛋白ASC招募procaspase-1，形成NLRP3炎性体。在NLRP3炎性体的作用下，pro-caspase-1被激活成为caspase-1，最终导致白细胞介素（IL）-1β和IL-18的成熟与分泌，引起一系列炎症反应。NLRP3炎性体在动脉粥样硬化、2型糖尿病、癌症等多种疾病中有重要作用，并且越来越多的证据表明NLRP3炎性体亦在心肌缺血再灌注损伤中发挥重要作用。本文介绍了NLRP3炎性体的基本结构和功能，并综述了NLRP3炎性体在心肌缺血再灌注损伤中作用的研究进展。

关键词: NLR家族, 热蛋白结构域包含蛋白3, 炎性体, 炎症, 活性氧, 心肌再灌注损伤, 微小RNAs, 综述

Abstract: Inflammasome is a multi-protein complex, which is a crucial constituent of innate immunity. NLRP3
inflammasome is the most extensively studied one. NLRP3 is composed of NLRP3, apoptosis associated spot like protein
(ASC) and pro-cysteine aspartate specific protease (caspase) - 1. When cells are stimulated, NLRP3 is activated and can
recruit pro-caspase-1 through the binding protein ASC to form NLRP3 inflammasome. Under the action of NLRP3
inflammasome, pro-caspase-1 is activated to caspase-1, which eventually leads to the maturation and secretion of IL-1 β
and IL-18, causing a series of inflammatory reactions. The NLRP3 inflammasome plays an important role in atherosclerosis,
type 2 diabetes, cancer and other diseases. There has been increasing evidence that NLRP3 inflammasome also plays an
important role in heart diseases, including myocardial ischemia/reperfusion injury (MI/RI). This article briefly introduces the
basic structure and function of NLRP3 inflammasome and reviews the research progress of the role of NLRP3 inflammasome
in the pathophysiology of MI/RI.

Key words: NLR family, pyrin domain-containing 3 protein, inflammasomes, inflammation, reactive oxygen species,  myocardial reperfusion injury, microRNAs, review