天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (9): 999-1001.doi: 10.11958/20180460

• 临床研究 • 上一篇    下一篇

鹿瓜多肽致Kounis综合征一例

王心慧，王明媚，卫晋菲，李莎，许玉莲   

  1. 解放军总医院第一附属医院药剂药理科临床药学室（邮编100048）
  • 收稿日期:2018-03-28 修回日期:2018-05-31 出版日期:2018-09-15 发布日期:2018-10-10
  • 通讯作者: 王心慧 E-mail:mylife0782@hotmail.com

One case of Kounis syndrome caused by cervus and cucumis polypeptide

WANG Xin-hui,WANG Ming-mei,WEI Jin-fei,LI Sha,XU Yu-lian   

  1. Department of Medicament and Pharmacology, the First Affiliated Hospital of People’s Liberation Army General Hospital, Beijing 100048, China
  • Received:2018-03-28 Revised:2018-05-31 Published:2018-09-15 Online:2018-10-10

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摘要： 鹿瓜多肽主要用于关节炎、强直性脊柱炎、各种类型骨折及腰腿疼痛等疾病，已广泛应用于临床。鹿瓜多肽引发过敏性心肌缺血综合征（Kounis综合征）的报道罕见。本文中患者既往无冠心病病史，因骨性关节炎使用鹿瓜多肽，静脉滴注1 min后出现Kounis综合征，经抗过敏及急性心肌缺血处理后痊愈出院。鹿瓜多肽作为临床常用药物，在使用时如出现急性心肌缺血表现，应警惕Kounis综合征可能，妥善处理。

关键词: 过敏反应, 心肌缺血, 鹿瓜多肽, Kounis综合征

Abstract: The cervus and cucumis polypeptide is widely used in clinical practice, mainly for arthritis, ankylosing spondylitis, various types of fractures, lumbocrural pain and other diseases. Reports of Kounis syndrome (anaphylaxis associated acute myocardial ischemia syndrome) caused by cervus and cucumis polypeptide are rare. In this paper, cervus and cucumis polypeptide was applied for osteoarthritis of the patient with no history of coronary heart disease. Kounis syndrome appeared after intravenous drip for one minute. The patient was cured and discharged after treatment with antianaphylaxis and acute myocardial ischemia. As a common clinical drug, the cervus and cucumis polypeptide should be alert to the possibility of Kounis syndrome if acute myocardial ischemia occurs.

Key words: anaphylaxis, myocardial ischemia, cervus and cucumis polypeptide, Kounis syndrome