脐带血IL-36γ水平与早期婴儿湿疹的关系分析

doi:10.11958/20230643

天津医药 ›› 2023, Vol. 51 ›› Issue (12): 1356-1359.doi: 10.11958/20230643

脐带血IL-36γ水平与早期婴儿湿疹的关系分析

卢旭俊¹^,²(), 王文革²^,^△(), 杨云月², 杨云彦²

1.河北北方学院研究生院（邮编075000）
2.空军军医大学空军特色医学中心儿科

收稿日期:2023-04-27 修回日期:2023-05-24 出版日期:2023-12-15 发布日期:2023-12-22
通讯作者: ^△ E-mail：1264516006@qq.com
作者简介:卢旭俊（1997），男，硕士在读，主要从事儿科学、皮肤病与性病学方面研究。E-mail：1102785962@qq.com
基金资助:
北京市科技计划项目(Z181100001718029);2022空军特色医学中心科技助推计划(2022ZTYB20)

Analysis of the relationship between IL-36γ level in umbilical cord blood and early infant eczema

LU Xujun¹^,²(), WANG Wenge²^,^△(), YANG Yunyue², YANG Yunyan²

1. Graduate School, Hebei North University, Zhangjiakou 075000, China
2. Department of Pediatrics, Air Force Medical Center, Air Force Medical Center University, PLA

Received:2023-04-27 Revised:2023-05-24 Published:2023-12-15 Online:2023-12-22
Contact: ^△ E-mail：1264516006@qq.com

卢旭俊, 王文革, 杨云月, 杨云彦. 脐带血IL-36γ水平与早期婴儿湿疹的关系分析[J]. 天津医药, 2023, 51(12): 1356-1359.

LU Xujun, WANG Wenge, YANG Yunyue, YANG Yunyan. Analysis of the relationship between IL-36γ level in umbilical cord blood and early infant eczema[J]. Tianjin Medical Journal, 2023, 51(12): 1356-1359.

摘要/Abstract

摘要：

目的探讨早期婴儿湿疹与脐带血白细胞介素（IL）-36γ水平的关系。方法选取足月健康新生儿59例为研究对象，收集性别、出生体质量、分娩方式等一般临床资料，以及母亲孕期海鲜类食物摄入次数是否≥3次。采用酶联免疫吸附试验检测新生儿脐带血IL-36γ水平。随访观察婴儿42 d内是否存在湿疹及其严重程度。多因素Logistic回归分析早期婴儿湿疹的影响因素，并绘制受试者工作特征（ROC）曲线评估IL-36γ的诊断效能。结果 59例婴儿中，40例患有湿疹，其中轻度35例，中度5例，19例无湿疹；湿疹组母亲孕期海鲜类食物摄入次数≥3次比例和脐带血IL-36γ水平高于无湿疹组（P<0.05）；轻度湿疹患者和中度湿疹患者中脐带血IL-36γ水平差异无统计学意义；多因素Logistic回归分析显示，脐带血IL-36γ水平升高以及母亲孕期海鲜类食物摄入次数≥3次是早期婴儿湿疹发生的危险因素（P<0.05）。ROC结果显示，脐带血IL-36γ预测早期婴儿湿疹发生的AUC（95%CI）为0.743（0.611~0.874），敏感度为87.6%，特异度为57.9%，截断值为103.823 ng/L。结论脐带血IL-36γ水平升高为早期婴儿湿疹的独立危险因素，早期检测对预测婴儿湿疹的发生有一定的价值。

关键词: 胎血, 湿疹, 婴儿, 过敏反应, IL-36γ

Abstract:

Objective To investigate the relationship between early infant eczema and cord blood interleukin (IL)-36γ level. Methods Fifty-nine full-term healthy newborns were selected as the study subjects. General information was collected including gender, birth weight, delivery method, gestational age, maternal age, physical fitness during pregnancy (diabetes, infection, hyperthyroidism and other complications), family history of allergies and intake times of seafood during pregnancy ≥3 times. The level of IL-36γ in umbilical cord blood after birth was detected by enzyme-linked immunosorbent assay. The presence and severity of eczema within 42 days were followed up. Multivariate Logistic regression was performed to analyze the influencing factors of early infant eczema, and receiver operating characteristics (ROC) were plotted to evaluate the diagnostic effectiveness. Results Among 59 infants, 40 had eczema, of which 35 were mild, 5 were moderate and 19 were eczema free. The proportion of seafood intake times ≥3 and the level of IL-36γ in umbilical cord blood were higher in the eczema group than those in the no-eczema group (P<0.05). There was no significant difference in IL-36γ level in cord blood between mild and moderate eczema patients. Multivariate Logistic regression analysis showed that the increased level of IL-36γ in umbilical cord blood and ≥3 intake times of seafood during pregnancy were risk factors for early infant eczema (P<0.05). ROC results showed that the AUC (95%CI) of umbilical cord blood IL-36γ was 0.743 (0.611-0.874), sensitivity was 87.6%, specificity was 57.9%, and truncation value was 103.823 ng/L. Conclusion The elevated level of IL-36γ in umbilical cord blood is an independent risk factor for early infant eczema, and early detection is valuable for predicting the occurrence of infantile eczema.

Key words: fetal blood, eczema, infant, anaphylaxis, interleukin 36γ

中图分类号:

R729

图/表 3

参考文献 32

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组别		n	性别（男/女）		出生体质量/g		分娩方式（剖宫产/顺产）			胎龄（<39周/39周~40周/>40周）
无湿疹组		19	10/9		3 257.90±242.26		9/10			4/9/6
湿疹组		40	18/22		3 345.00±339.46		16/24			6/25/9
χ²或t			0.301		1.002		0.286			1.208
组别	母亲年龄/岁			喂养方式（母乳喂养/混合喂养）		家族过敏史（有/无）		孕期是否体健（是/否）	孕期海鲜类食物摄入次数≥3次（有/无）
无湿疹组	32.00±3.40			13/6		17/2		10/9	5/14
湿疹组	31.48±3.90			21/19		29/11		16/24	23/17
χ²或t	0.498			1.337		1.285		0.834	5.024^＊

组别		n	性别（男/女）		出生体质量/g		分娩方式（剖宫产/顺产）			胎龄（<39周/39周~40周/>40周）
无湿疹组		19	10/9		3 257.90±242.26		9/10			4/9/6
湿疹组		40	18/22		3 345.00±339.46		16/24			6/25/9
χ²或t			0.301		1.002		0.286			1.208
组别	母亲年龄/岁			喂养方式（母乳喂养/混合喂养）		家族过敏史（有/无）		孕期是否体健（是/否）	孕期海鲜类食物摄入次数≥3次（有/无）
无湿疹组	32.00±3.40			13/6		17/2		10/9	5/14
湿疹组	31.48±3.90			21/19		29/11		16/24	23/17
χ²或t	0.498			1.337		1.285		0.834	5.024^＊

变量	β	SE	Wald χ²	P	OR	OR 95%CI
母亲孕期海鲜类食物摄入次数≥3次	1.594	0.677	5.534	0.019	4.919	1.305~18.550
脐带血IL-36γ水平	0.002	0.001	4.430	0.035	1.002	1.000~1.004

变量	β	SE	Wald χ²	P	OR	OR 95%CI
母亲孕期海鲜类食物摄入次数≥3次	1.594	0.677	5.534	0.019	4.919	1.305~18.550
脐带血IL-36γ水平	0.002	0.001	4.430	0.035	1.002	1.000~1.004

脐带血IL-36γ水平与早期婴儿湿疹的关系分析

Analysis of the relationship between IL-36γ level in umbilical cord blood and early infant eczema

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