天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (2): 192-202.doi: 10.11958/20181281

• 循证医学 • 上一篇    下一篇

血清CA 19-9浓度与卵巢成熟性囊性畸胎瘤相关性的Meta分析

张超△， 傅金瑞， 王高升   

  1. 天津市宝坻区人民医院医学检验科 （邮编301800）
  • 收稿日期:2018-08-27 修回日期:2019-01-10 出版日期:2019-02-15 发布日期:2019-02-15
  • 通讯作者: 张超 E-mail:tjykdxzc@126.com

Correlation between serum CA 19-9 levels and ovarian mature cystic teratoma: a Meta-analytic review

ZHANG Chao△, FU Jin-rui, WANG Gao-sheng   

  1. Department of Medical Laboratory, Tianjin Baodi District People’ s Hospital, Tianjin 301800, China
  • Received:2018-08-27 Revised:2019-01-10 Published:2019-02-15 Online:2019-02-15
  • Contact: zhang chao E-mail:tjykdxzc@126.com

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摘要：  目的 系统评价血清糖类抗原19-9 （CA 19-9） 浓度与卵巢成熟性囊性畸胎瘤的相关性。方法 计算机检索Pubmed、 CNKI、 CBMdisc和万方数据库， 收集关于卵巢成熟性囊性畸胎瘤与血清CA 19-9浓度相关研究的文献。由2名评价员独立对纳入的文献进行质量评价和数据提取， 将纳入文献分别按照成熟性畸胎瘤与未成熟性畸胎瘤、单双侧患病、 是否合并肿瘤蒂扭转、 肿瘤组织是否含有神经组织和甲状腺组织进行分组， 采用Review Manager 5.3进行Meta分析。结果 共纳入53篇文献， 分组比较结果： 成熟性畸胎瘤组 （1 398例） CA 19-9浓度低于未成熟性畸胎瘤组 （145例）（P＜0.001）； 双侧肿瘤组 （614例） 的CA 19-9浓度高于单侧肿瘤组 （3 126例）（P＜0.001）； 合并肿瘤蒂扭转组 （18例） CA 19-9浓度高于无合并肿瘤蒂扭转组 （374例）（P＜0.001）； 肿瘤组织中有神经组织组 （364例） 与无神经组织组 （1 305例） CA 19-9阳性率差异无统计学意义 （P=0.300）； 肿瘤组织中有甲状腺组织组 （35例） 的CA 19-9阳性率高于无甲状腺组织组 （1 135例）（P=0.030）。CA 19-9阳性率随年龄增加而降低， 随肿瘤增大而升高 （r分别为-0.818和0.927， 均P＜0.001）。结论 CA 19-9浓度与MCT有显著的关联， 低龄者浓度更高， 且其浓度增高可能提示患者肿瘤体积较大， 有恶变、 双侧患病、 合并肿瘤蒂扭转等并发症、 以及混杂有甲状腺组织等的可能。

关键词: Meta分析, 成熟性囊性畸胎瘤, CA 19-9

Abstract:  Objective To study the correlation between CA 19-9 levels and ovarian mature cystic teratoma systematically. Methods Data of the correlation between CA 19-9 and mature cystic teratoma were searched and collected from the database of Pubmed, CNKI, CBMdisc, and Wanfang. Two evaluators independently evaluated the quality of the literature and extracted the data. The literature will be grouped according to mature teratoma and immature teratoma, unilateral or bilateral lesions, with or without torsion, with or without neural tissue and thyroid tissue. Review Manager 5.3 was used for Meta-analysis. Results A total of 53 articles were included. The results were as follows: the concentration of CA 19-9 was lower in mature teratoma group (n=1 398) than that in immature teratoma group (n=145, P＜0.001). The concentration of CA 19-9 was higher in bilateral tumor group (n=614) than that in unilateral tumor group (n=3 126, P＜ 0.001). The concentration of CA 19-9 was higher in patients with tumor torsion group (n=18) than that in non-tumor torsion group (n=374, P＜0.001). There was no significant difference in the positive rate of CA 19-9 between the tumor group with nerve tissue (n=364) and the tumor group without nerve tissue (n=1 305, P=0.300). The positive rate of CA 19-9 was higher in the tumor tissue with thyroid tissue group (n=35) than that in tumor tissue without thyroid tissue group (n=1 135, P= 0.030). The positive rate of CA 19-9 decreased with the increase of age (r=- 0.818, P＜0.001) and increased with the increase of tumor size (r=0.927, P＜0.001). Conclusion There is a significant correlation between CA 19-9 concentration and MCT. There is higher concentration of CA 19-9 in the younger age group, which may indicate that the tumor is large, with the possibility of malignant, bilateral lesions, complications like tumor torsion, and the possibility of mixed thyroid tissue.

Key words: Meta-analysis, mature cystic teratoma, CA 19-9