天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (8): 874-879.doi: 10.11958/20182145

• 综述 • 上一篇    下一篇

高致病性H7N9禽流感病毒研究进展

董晓春   

  1. 天津市疾病预防控制中心（邮编300011）
  • 收稿日期:2018-12-29 修回日期:2019-05-27 出版日期:2019-08-15 发布日期:2019-08-16
  • 通讯作者: 董晓春 E-mail:dwz90876@126.com
  • 作者简介:董晓春（1981），男，副主任医师，硕士，主要从事呼吸道传染病方面研究
  • 基金资助:
    国家科技重大专项艾滋病和病毒性肝炎等重大传染病防治项目

Research progress of highly pathogenic H7N9 avian influenza virus

DONG Xiao-chun   

  1. Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China
  • Received:2018-12-29 Revised:2019-05-27 Published:2019-08-15 Online:2019-08-16
  • Contact: Xiao-Chun DONG E-mail:dwz90876@126.com

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摘要： 摘要：H7N9禽流感病毒在中国出现以来共造成5次流行。在第5次流行中出现了高致病性H7N9变异株，该病 毒株的HA链接肽位置发生了基因插入性突变，导致该病毒对家禽毒力的增强。同时在人感染H7N9禽流感病例中 也相继分离到了该病毒。因此，对高致病性H7N9禽流感病毒病原学及流行病学研究对于该疾病的预防和控制具有 重要意义。本文从高致病性H7N9禽流感病毒的变异来源、流行病学特征及防治措施等方面进行综述，为高致病性 H7N9禽流感的有效防治提供科学策略。

关键词: 禽流感, 甲型流感病毒, H7N9亚型, 流行病学, 病原学

Abstract: Abstract：Since the appearance of H7N9 avian influenza virus in China, it has caused five waves of epidemics. A highly pathogenic H7N9 mutant strain has appeared in the 5th wave of the epidemics. The insertion mutation of the HA linked peptide position of the virus strain resulted in the virulence enhancement of the virus to poultry. At the same time, the virus was isolated from human H7N9 avian influenza cases. Therefore, the etiology and epidemiology of highly pathogenic H7N9 avian influenza virus are of great significance for the prevention and control of the disease. This article reviews the mutation sources, epidemiological characteristics and control measures of highly pathogenic H7N9 avian influenza virus, and provides scientific strategies for the effective prevention and control of highly pathogenic H7N9 avian influenza.

Key words: influenza in birds, influenza A virus, H7N9 subtype, epidemiology, etiology