天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (9): 979-982.doi: 10.11958/20190600

• 临床研究 • 上一篇    下一篇

直肠癌组织中HIF-1α和Survivin的表达及对新辅助放化疗后肿瘤退缩的预测价值

司志龙，李运奇，胡波，桂华伟，肖飞△   

  1. 作者单位：武汉市第四医院，华中科技大学同济医学院附属普爱医院（邮编430032） 作者简介：司志龙（1986），男，硕士，主治医师，主要从事结直肠恶性肿瘤规范化治疗方面的研究 △通讯作者 E-mail: szl19860627@163.com
  • 收稿日期:2019-03-04 修回日期:2019-07-01 出版日期:2019-09-15 发布日期:2019-09-18
  • 通讯作者: 肖飞 E-mail:szl19860627@163.com

The predictive values of expressions of HIF-1α and Survivin in rectal cancer tissues for tumor regression after neoadjuvant chemoradiotherapy

SI Zhi-long, LI Yun-qi, HU Bo, GUI Hua-wei, XIAO Fei△   

  1. Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430032, China △Corresponding Author E-mail: szl19860627@163.com
  • Received:2019-03-04 Revised:2019-07-01 Published:2019-09-15 Online:2019-09-18

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摘要： 目的 探讨缺氧诱导因子（HIF）-1α和凋亡抑制蛋白生存素（Survivin）在直肠癌组织中的表达及对直肠癌 新辅助放化疗后肿瘤退缩效果的预测价值。方法 回顾性分析我院2014年4月—2018年8月新辅助放化疗后行全 直肠系膜切除术（TME）的直肠癌患者83例，采用免疫组织化学染色法检测肿瘤组织中HIF-1α和Survivin的表达情 况，应用Spearman等级相关检验分析HIF-1α和Survivin表达的关系，应用AJCC-TRG评分系统对放化疗后肿瘤退缩 效果进行评价，分析HIF-1α和Survivin同肿瘤退缩效果之间的关系。结果 免疫组化显示HIF-1α和Survivin在本 组患者癌组织中的阳性表达率分别为61.4%（51/83）、67.5%（56/83），且表达呈正相关（rs=0.587，P＜0.01）。本组患者 新辅助治疗后总有效率为55.4%（46/83），完全退缩13例，中等退缩33例，轻微退缩20例，无退缩17例。患者癌组织 中HIF-1α和Survivin的表达与肿瘤退缩效果有关，HIF-1α和Survivin同时阳性者有效率35.3%（12/34），明显低于其 他组别。结论 HIF-1α和Survivin在直肠癌组织中的表达呈正相关，两者的表达状态可以为预测直肠癌新辅助放化 疗后肿瘤退缩的效果提供依据。

关键词: 直肠肿瘤, 缺氧诱导因子1, α亚基, 放化疗, 辅助, Survivin, 肿瘤退缩

Abstract: Objective To investigate the expressions of hypoxia-inducible factor-1α (HIF-1α) and apoptotic inhibitory protein Survivin in rectal cancer tissues and their predictive values for tumor regression after neoadjuvant chemoradiotherapy. Methods A retrospective analysis was performed on 83 rectal cancer patients who underwent total mesorectal resection (TME) after neoadjuvant radiotherapy and chemotherapy in our hospital from April 2014 to August 2018. Immunohistochemical method was used to detect the expressions of HIF-1α and Survivin in tumor tissues. Spearman rank correlation test was performed to analyze the relationship between HIF-1α and Survivin expressions. AJCC-TRG scoring system was employed to evaluate the effect of tumor regression after radiotherapy and chemotherapy. The relationship between tumor regression and HIF-1α/Survivin was analyzed. Results Immunohistochemistry showed that the positive expression rates of HIF-1α and Survivin in cancer tissues were 61.4% (51/83) and 67.5% (56/83), respectively. Expressions of HIF-1α and Survivin were positively correlated, and the spearman correlation coefficient was rs=0.587 (P＜0.001). The total effective rate of patients after neoadjuvant therapy was 55.4% (46/83), with 13 cases of complete withdrawal, 33 cases of moderate withdrawal, 20 cases of mild withdrawal and 17 cases of non-withdrawal. Analysis showed that the expressions of HIF-1α and Survivin were correlated with tumor regression. The effective rate of patients with HIF-1α (+)/Survivin (+) was 35.3% (12/34), which was significantly lower than that of other groups. Conclusion There is a positive correlation between the expressions of HIF-1α and Survivin in rectal cancer tissues. The expressions of HIF- 1α and Survivin can provide a basis for predicting the regression effect after neoadjuvant chemoradiotherapy in rectal cancer.

Key words: rectal neoplasms, hypoxia-inducible factor 1, alpha subunit, chemoradiotherapy, adjuvant, Survivin, tumor regression