天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (4): 343-347.doi: 10.11958/20192717

• 综述 • 上一篇    下一篇

STAT3信号通路在胰岛素抵抗中的研究进展 #br#

刘宏飞，魏翠英△
  

  1. 内蒙古科技大学包头医学院第一附属医院（邮编 014010）
  • 收稿日期:2019-09-02 修回日期:2019-12-21 出版日期:2020-04-15 发布日期:2020-06-23
  • 通讯作者: 魏翠英 E-mail:weicuiying9@163.com
  • 作者简介:刘宏飞（1994），女，硕士在读，主要从事糖代谢方面研究
  • 基金资助:
    阻塞型睡眠呼吸暂停综合征对糖尿病患者24小时血糖动态变化的影响及 其机制的初步研究

Research progress of STAT3 signaling pathway in insulin resistance #br#

LIU Hong-fei, WEI Cui-ying△ #br#   

  1. The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology,
    Baotou 014010, China
  • Received:2019-09-02 Revised:2019-12-21 Published:2020-04-15 Online:2020-06-23
  • Contact: WEI Cui-ying E-mail:weicuiying9@163.com
  • Supported by:

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摘要： 胰岛素抵抗（IR）是 2型糖尿病的重要发生机制，通过影响多种信号通路传导，从而使糖代谢紊乱，信号传
导与转录激活因子 3（STAT3）通路是一种调控基因转录的重要通路。有证据表明，STAT3信号通路是 IR的关键因
子，能够调节有丝分裂原活化蛋白激酶（MAPK）通路、胰岛素受体底物-1（IRS-1）/磷脂酰肌醇 3激酶（P13K）/蛋白激
酶 B（PKB）通路等胰岛素相关通路。STAT3信号通路被上游细胞因子白细胞介素-22（IL-22）激活，参与糖代谢调
节，目前是研究热点，本文就 STAT3通路与 IR的关系进行综述，旨在进一步阐明糖代谢紊乱机制，为糖尿病治疗提供
新思路。

关键词: 糖尿病, 2型, STAT3信号通路, 胰岛素抵抗

Abstract: Insulin resistance (IR) is an important mechanism of type 2 diabetes. It affects the transmission of various
signaling pathways, thereby disrupting glucose metabolism. Signaling and the transcriptional activation factor 3 (STAT3)
pathway are important pathways that regulate gene transcription. There is evidence that STAT3 signaling pathway is a key
factor of IR, which can regulate the mitogen-activated protein kinase (MAPK) pathway, insulin receptor substrate-1 (IRS-1) /phosphatidyl inositol 3 kinase (P13K) / protein kinase B (PKB) pathway and other insulin-related pathways. The STAT3
signaling pathway is activated by the upstream cytokine interleukin-22 (IL-22) and is involved in the regulation of glucose
metabolism. It is a current research hotspot. This article reviews the relationship between the STAT3 pathway and IR to
further clarify the pathogenesis of glucose metabolism.

Key words: diabetes mellitus, type 2, STAT3 signaling pathway, insulin resistance

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