天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (10): 1010-1014.doi: 10.11958/20200130

• 综述 • 上一篇    下一篇

黄酮类化合物抗卵巢癌化疗耐药的作用进展

林世鑫1，高军2△   

  1. 1南昌大学江西医学院（邮编330008）；2南昌大学第三附属医院妇产科
  • 收稿日期:2020-01-13 修回日期:2020-05-17 出版日期:2020-10-15 发布日期:2020-10-30
  • 通讯作者: 高军 E-mail:gaojun19777@163.com
  • 基金资助:
    江西省卫生计生委科技计划;江西省卫生计生委中医药科研课题

Progress in the effect of flavonoids on drug resistance in ovarian cancer

LIN Shi-xin1, GAO Jun2△   

  1.  1 Jiangxi Medical College of Nanchang University, Nanchang 330008, China; 2 Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Nanchang University
  • Received:2020-01-13 Revised:2020-05-17 Published:2020-10-15 Online:2020-10-30

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摘要：

摘要：黄酮类化合物是广泛存在于自然界的一类多酚类物质，亦是诸多传统中草药中的有效成分之一，因其高效、低毒，且具有多种生物学活性而得到了广泛的关注。卵巢癌是病死率最高的妇科恶性肿瘤，化疗耐药是导致其预后不良的主要原因之一。研究发现，黄酮类化合物对改善卵巢癌耐药有独特的效果，或将有助于克服卵巢癌耐药。本文就近年来黄酮类化合物改善卵巢癌化疗耐药作用的相关研究进展进行综述。

关键词: 卵巢肿瘤；抗药性, 肿瘤；黄酮类；化疗耐药；天然药物

Abstract:

Abstract:Ovarian cancer is the most lethal gynaecological cancer. And chemotherapy resistance is one of the main reasons for its poor prognosis. Recently, some natural products have been reported to overcome drug resistance, including flavonoids that are abundant in plants, foods, and are also one of the active ingredients in many traditional Chinese herbal medicines. Because of their characteristics of broad biological activity, high efficiency, low toxicity, good prevention and cure effects on various types of tumors, flavonoids have received extensive attention. Here, we summarize the research and discuss the underlying mechanisms, concluding that these flavonoids do not function as specific regulators of target proteins, but rather as multi-functional agents that negatively regulate the key factors contributing to drug resistance of ovarian cancer.

Key words:  ovarian neoplasms, drug resistance, neoplasm, flavones, drug resistance, natural products