关键词: 外泌体, 胞外囊泡, 自噬, 微RNAs, 信号通路

Abstract: Abstract: Exosomes are bilayer lipid membrane vesicles formed by the fusion and release of encapsulated polycystic body and cell membrane into the extracellular environment. Exosomes are rich in proteins, RNA and lipids, which can mediate intercellular communication and participate in various physiological and pathological processes. Autophagy is a process, in which cells encapsulate organelles, proteins and RNA that need to be degraded in the double-layer membrane vesicles to form autophagosomes, and combine with lysosomes to form autophagosomes and degrade contents. In recent years, many studies have revealed the molecular mechanism of the interaction between exosomes and autophagy, and found that the mTOR signaling pathway, toll-like receptor signaling pathway and STAT3/Bcl-2 signaling pathway are all important related pathways for exosomes to regulate autophagy and participate in the process of exosomes to regulate autophagy. In this paper, the mechanism of exosome regulating autophagy and its research progress are reviewed, which will provide new inspiration and help for future research on the application of exosome regulating autophagy in more diseases.

Key words: exosome, extracellular vesicles, autophagy, microRNAs, signaling pathway