5-羟色胺在胃肠道疾病中的作用及其机制研究进展

doi:10.11958/20231309

天津医药 ›› 2024, Vol. 52 ›› Issue (4): 438-442.doi: 10.11958/20231309

5-羟色胺在胃肠道疾病中的作用及其机制研究进展

单子鸿¹(), 胡晓青², 李峰³, 黄永坤¹^,^△()

1 昆明医科大学第一附属医院儿科（邮编650000）
2 嘉善县第一人民医院老年科
3 昆明市儿童医院儿科

收稿日期:2023-09-11 修回日期:2023-10-30 出版日期:2024-04-15 发布日期:2024-04-19
通讯作者: ^△E-mail：hykkmyncnwd@163.com
作者简介:单子鸿（1994），男，博士在读，主要从事消化系统疾病方面研究。E-mail：shanzihong1994@163.com
基金资助:
国家自然科学基金资助项目(81960102)

Research progress on the role and mechanism of 5-hydroxytryptamine in gastrointestinal diseases

SHAN Zihong¹(), HU Xiaoqing², LI Feng³, HUANG Yongkun¹^,^△()

1 Department of Pediatrics, the 1st Affiliated Hospital of Kunming Medical University, Kunming 650000, China
2 Department of Geriatrics, the 1st People's Hospital of Jiashan
3 Department of Pediatrics, Kunming Children's Hospital

Received:2023-09-11 Revised:2023-10-30 Published:2024-04-15 Online:2024-04-19
Contact: ^△E-mail：hykkmyncnwd@163.com

单子鸿, 胡晓青, 李峰, 黄永坤. 5-羟色胺在胃肠道疾病中的作用及其机制研究进展[J]. 天津医药, 2024, 52(4): 438-442.

SHAN Zihong, HU Xiaoqing, LI Feng, HUANG Yongkun. Research progress on the role and mechanism of 5-hydroxytryptamine in gastrointestinal diseases[J]. Tianjin Medical Journal, 2024, 52(4): 438-442.

摘要/Abstract

摘要：

5-羟色胺（5-HT）是脑-肠轴途径中一种重要的神经递质，其分泌与肠道菌群、肠道免疫、肠道动力等方面密切相关。5-HT代谢途径异常参与肠易激综合征、炎症性肠病、慢性便秘、功能性消化不良等胃肠道疾病的发生、发展。就5-HT在不同胃肠道疾病中的作用机制研究进行综述，以期为临床治疗开拓新思路。

关键词: 血清素, 5-羟色胺, 胃肠道疾病, 肠道菌群, 肠道动力, 肠道免疫

Abstract:

5-hydroxytryptamine (5-HT) is an important neurotransmitter in brain-gut axis pathway, and its secretion is closely related to intestinal flora, intestinal immunity and intestinal motility. Abnormal metabolic pathway of 5-HT is involved in the occurrence and development of gastrointestinal diseases, such as irritable bowel syndrome, inflammatory bowel disease, chronic constipation and functional dyspepsia. This article reviews the mechanism of 5-HT in different gastrointestinal diseases in order to explore new ideas for clinical treatment.

Key words: serotonin, 5-hydroxytryptamine, gastrointestinal diseases, intestinal flora, intestinal motility, intestinal immunity

中图分类号:

R574

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5-羟色胺在胃肠道疾病中的作用及其机制研究进展

Research progress on the role and mechanism of 5-hydroxytryptamine in gastrointestinal diseases

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