葡萄糖依赖性促胰岛素多肽与多囊卵巢综合征相关性的研究进展

doi:10.11958/20240051

天津医药 ›› 2024, Vol. 52 ›› Issue (9): 996-999.doi: 10.11958/20240051

葡萄糖依赖性促胰岛素多肽与多囊卵巢综合征相关性的研究进展

范哲华¹(), 刘建荣²^,^△()

1 山西医科大学第五临床医学院（邮编030000）
2 山西省人民医院生殖医学科

收稿日期:2023-01-09 修回日期:2024-02-25 出版日期:2024-09-15 发布日期:2024-09-06
通讯作者: ^△E-mail：liujianrong3@sina.com
作者简介:范哲华（1996），女，硕士在读，主要从事不孕症及辅助生殖方面研究。E-mail：564594755@qq.com
基金资助:
国家自然科学基金资助项目(81973864);中央引导地方科技发展资金项目(YDZJSX2022A069)

Advances in the study of the correlation between incretin hormone GIP and polycystic ovary syndrome

FAN Zhehua¹(), LIU Jianrong²^,^△()

1 The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China
2 Reproductive Medical Center, Shanxi Provincial People’s Hospital

Received:2023-01-09 Revised:2024-02-25 Published:2024-09-15 Online:2024-09-06
Contact: ^△E-mail：liujianrong3@sina.com

范哲华, 刘建荣. 葡萄糖依赖性促胰岛素多肽与多囊卵巢综合征相关性的研究进展[J]. 天津医药, 2024, 52(9): 996-999.

FAN Zhehua, LIU Jianrong. Advances in the study of the correlation between incretin hormone GIP and polycystic ovary syndrome[J]. Tianjin Medical Journal, 2024, 52(9): 996-999.

摘要/Abstract

摘要：

多囊卵巢综合征（PCOS）是育龄妇女常见的生殖和内分泌疾病之一，机制未明，但胰岛素抵抗、高雄激素血症、肥胖是其重要的病理生理基础。葡萄糖依赖性促胰岛素多肽（GIP）是一种参与调控胰岛素分泌的胃肠激素，与胰岛素抵抗、高雄激素血症、肥胖等PCOS的特征性改变具有相关性，可能通过影响下丘脑-垂体-卵巢轴的功能促进PCOS的发生与发展，提示GIP与PCOS相关。就GIP与PCOS相关性的研究现状进行综述。

关键词: 多囊卵巢综合征, 肥胖症, 胰岛素抵抗, 葡萄糖依赖性促胰岛素多肽, 高雄激素血症, 下丘脑-垂体-卵巢轴

Abstract:

Polycystic ovary syndrome (PCOS) is one of the most common reproductive and endocrine disorders in women of childbearing age, and the pathogenesis is unknown. Insulin resistance, hyperandrogenism and obesity are important pathophysiological basis. Glucose-dependent insulinotropic peptide (GIP) is a gastrointestinal hormone involved in the regulation of insulin secretion. Literature studies have shown that GIP is correlated with insulin resistance, hyperandrogenism, obesity and other characteristic changes of PCOS, and it may contribute to the onset and progression of PCOS by affecting the function of hypothalamic-pituitary-ovarian axis, suggesting that GIP is associated with PCOS. This paper reviews the research progress of the correlation between GIP and PCOS.

Key words: polycystic ovary syndrome, obesity, insulin resistance, glucose-dependent insulinotropic polypeptide, hyperandrogenism, hypothalamic-pituitary-ovarian axis

中图分类号:

R711.75，R588.6

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葡萄糖依赖性促胰岛素多肽与多囊卵巢综合征相关性的研究进展

Advances in the study of the correlation between incretin hormone GIP and polycystic ovary syndrome

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