• 实验研究 •    

颈椎射频消融髓核成形术病理转归的实验研究

张涛1,孙玉福2,高中玉2,李彦敏2,唐玮2,冯世庆2   

  1. 1. 天津市第一中心医院
    2.
  • 收稿日期:2009-11-02 修回日期:2010-01-04 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 张涛

An experimental study of percutaneous nucleoplasty of the cervical intervertebral disc

  • Received:2009-11-02 Revised:2010-01-04 Published:2010-09-15 Online:2010-09-15
  • Contact: ZHANG Tao

摘要: 摘要 目的:探讨等离子射频消融髓核成形术后颈椎间盘的病理变化。方法:选用10只成年小尾寒羊,模拟临床对羊的颈椎间盘髓核行等离子射频消融术,术后即刻、2 周及 4 周分别处死羊 2 只、4只、4只,光学显微镜下观察消融椎间盘的病理变化。结果:术后即刻标本显示髓核内出现椭圆形空洞,空洞长轴直径1.5mm~2.3mm,短轴直径0.4~0.7mm,临近消融区域的纤维环和终板无损伤,2周标本显示其髓核内空洞缩小,4周标本显示空洞被纤维组织填充。结论:颈椎间盘等离子射频消融髓核成形术后髓核组织内无炭化效应,终板、韧带无热损伤反应;消融形成的空洞被髓核和纤维组织修复,是一种安全的手术方式。

关键词: 髓核成形, 椎间盘, 颈椎, 动物, 组织学

Abstract: Abstract Objective: To determine the histologic changes of the cervical intervertebral discs and surrounding tissues after nucleoplasty. Methods:The experimental study was performed in 10 sheep, and each sheep was treated with nucleoplasty in C4-5 and C5-6. Chronic histologic changes were observed by light microscopy at 0,2,4 weeks after cervical nucleoplasty. Results:Two sheep were euthanized immediately after treatment, and the oval-shaped cavities were observed on the macroscopic view in the nucleus pulposus. The cavities measured between 1.5 mm to 2.3mm in long axis and between 0.4mm to 0.7mm in short. 2 weeks after nuleoplasty, the cavities were shortened. 4 weeks after nucleoplasty, the cavities was replaced by nucleus pulposus and fibrous tissues. Condusion: Nucleoplasty did not result in thermal damage or other significant damaging effects to the adjacent annulus and end plate, the cavities produced by nucleoplasty were rehabilitated finally. Nucleoplasty is a safe procedure to cervical spine.

Key words: Nucleoplasty, Intervertebral disc, Cervical vertebrae, Animals, Histology