天津医药

• 实验研究 •    

颈椎射频消融髓核成形术病理转归的实验研究

张涛1,孙玉福2,高中玉2,李彦敏2,唐玮2,冯世庆2   

  1. 1. 天津市第一中心医院
    2.
  • 收稿日期:2009-11-02 修回日期:2010-01-04 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 张涛

An experimental study of percutaneous nucleoplasty of the cervical intervertebral disc

  • Received:2009-11-02 Revised:2010-01-04 Published:2010-09-15 Online:2010-09-15
  • Contact: ZHANG Tao

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摘要： 摘要 目的：探讨等离子射频消融髓核成形术后颈椎间盘的病理变化。方法：选用10只成年小尾寒羊，模拟临床对羊的颈椎间盘髓核行等离子射频消融术，术后即刻、2 周及 4 周分别处死羊 2 只、4只、4只，光学显微镜下观察消融椎间盘的病理变化。结果：术后即刻标本显示髓核内出现椭圆形空洞，空洞长轴直径1.5mm～2.3mm，短轴直径0.4～0.7mm，临近消融区域的纤维环和终板无损伤，2周标本显示其髓核内空洞缩小，4周标本显示空洞被纤维组织填充。结论：颈椎间盘等离子射频消融髓核成形术后髓核组织内无炭化效应，终板、韧带无热损伤反应；消融形成的空洞被髓核和纤维组织修复，是一种安全的手术方式。

关键词: 髓核成形, 椎间盘, 颈椎, 动物, 组织学

Abstract: Abstract Objective: To determine the histologic changes of the cervical intervertebral discs and surrounding tissues after nucleoplasty. Methods：The experimental study was performed in 10 sheep, and each sheep was treated with nucleoplasty in C4-5 and C5-6. Chronic histologic changes were observed by light microscopy at 0，2，4 weeks after cervical nucleoplasty. Results：Two sheep were euthanized immediately after treatment, and the oval-shaped cavities were observed on the macroscopic view in the nucleus pulposus. The cavities measured between 1.5 mm to 2.3mm in long axis and between 0.4mm to 0.7mm in short. 2 weeks after nuleoplasty, the cavities were shortened. 4 weeks after nucleoplasty, the cavities was replaced by nucleus pulposus and fibrous tissues. Condusion: Nucleoplasty did not result in thermal damage or other significant damaging effects to the adjacent annulus and end plate, the cavities produced by nucleoplasty were rehabilitated finally. Nucleoplasty is a safe procedure to cervical spine.

Key words: Nucleoplasty, Intervertebral disc, Cervical vertebrae, Animals, Histology