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HR-HPV在诊断高级别宫颈上皮内瘤样病变中的价值

田静1,瞿全新2   

  1. 1. 天津医科大学第一中心临床学院妇产科
    2. 天津医科大学一中心临床学院
  • 收稿日期:2012-07-18 修回日期:2013-03-01 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 田静

The Clinical Value of HR-HPV on the Diagnosing High-grade Cervical Intraepithelial Neoplasia

  • Received:2012-07-18 Revised:2013-03-01 Published:2013-06-15 Online:2013-06-15

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摘要： 【摘要】目的  研究高危型人乳头状瘤病毒（HR-HPV）在诊断高级别宫颈上皮内瘤样病变（CIN）中的价值。方法   A组43例，包括慢性宫颈炎及CINⅠ；B组71例，包括CINⅡ～Ⅲ。宫颈细胞学筛查采用液基薄层细胞学检测技术，利用基因组抽提试剂盒提取DNA进行HPV DNA检测，比较宫颈细胞学筛查、HPV检测及联合检测的诊断准确率。结果  单独以宫颈细胞学、HR-HPV及宫颈细胞学联合HR-HPV诊断高级别CIN的敏感度分别为83.1%，88.7%，91.5%，特异度分别为14.0%，48.8%，58.1%，阳性预测值分别为61.5%，74.1%，78.3%，阴性预测值分别为33.3%，72.4%，80.6%，诊断效率分别为57.0%，73.7%,78.9%。结论  HR-HPV及HR-HPV联合宫颈细胞学检测宫颈高级别CIN的诊断准确率高于宫颈细胞学检测。

关键词: 乳头状瘤病毒科, 宫颈肿瘤, 癌, 宫颈上皮内瘤样病变, 筛查

Abstract: Abstract   Objective  To study the clinical value of HR-HPV on the diagnosing high-grade cervical intraepithelial neoplasia(CIN).Methods: We splited 114 patients with different results of cervical pathology into two groups, group A had 43 cases, including chronic cervicitis and CIN I ;group B had 71 cases, including CIN II-III .The diagnostic efficiency of the cervical cytological screening with TCT,HPV virus testing with genomic extraction kit and Cotesting were contrasted. Results   High-grade CIN was only predicted by cervical cytological testing，HR-HPV，cervical cytological testing combined with HR-HPV testing where, the sensitivity were 83.1%,88.7%,91.5%,the specificity were 14.0%,48.8%,58.1%, the positive-predictive value were 61.5%,74.1%,78.3%, the negative-predictive value were 33.3%,72.4%, 80.6% , the diagnostic efficiency were 57.0 %,73.7%, 78.9%, respectively. The diagnostic efficiency of high-grade CIN by HPV testing and Cotesting were better than cervical cytological testing（p<0.05, p<0.05）.Conclusions    The diagnostic efficiency of high-grade CIN by HR-HPV testing and HR-HPV testing combined with cervical cytological testing was better than cervical cytological testing.

Key words: papillomaviridae, uterine cervical neoplasms, carcinoma, cervical intraepithelial neoplasia, Screening