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DKK1、SFRP4和Wnt1在宫颈鳞癌中的表达及意义

侯安丽   

  1. 承德医学院附属医院
  • 收稿日期:2013-03-27 修回日期:2013-07-02 出版日期:2013-11-15 发布日期:2013-11-15
  • 通讯作者: 侯安丽

The Expression and Clinical Significance of DKK1, SFRP4and Wnt1in Cervical Squamous Cell Carcinoma

HOU An li   

  1. Department of Gynecology, The Affiliated Hospital of Chengde Medical College
  • Received:2013-03-27 Revised:2013-07-02 Published:2013-11-15 Online:2013-11-15
  • Contact: HOU An li

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摘要：

【摘要】  目的  研究Wnt信号通路抑制因子DKK1、分泌型卷曲相关蛋白（SFRP)4及Wnt基因家族因子（Wnt1）在宫颈鳞癌中的表达及其临床意义。  方法  76例宫颈癌患者病理标本为SCC组，36例子宫良性肿瘤切除标本为对照组（NC组），应用免疫组化法检测DKK1、SFRP4及Wnt1在SCC组及NC组中的表达。  结果  DKK1在SCC组的表达低于NC组（P<0.05)。SFRP4及Wnt1在SCC组的表达均高于NC组（P<0.05)。DKK1、SFRP4及Wnt1在不同临床病理分期、组织分化程度、肿瘤大小及有无淋巴结转移SCC患者间表达差异有统计学意义（均P<0.05）。宫颈鳞癌中DKK1与SFRP4、Wnt1的表达均呈负相关（均P<0.05），SFRP4与Wnt1在宫颈鳞癌中的表达呈正相关（P<0.05）。  结论  SFRP4和Wnt1在宫颈鳞癌的发生中可能存在协同作用，而DKK1可能作为宫颈鳞癌的抑制因子发挥作用。

关键词: 宫颈肿瘤, 癌, 鳞状细胞, Wnt1蛋白质, 免疫组织化学, DKK1, 分泌型卷曲相关蛋白4

Abstract:

 [Abstract]   Objective  To investigate the expressions of DKK1，SFRP4and Wnt1in cervical squamous cell carcino-ma(SCC), and the clinical significance thereof.   Methods   There were76samples of cervical squamous cell carcinoma were included in SCC group and 36benign uterine resection specimens were control group (NC). The immunohistochemical method was applied to detect the expressions of DKK1，SFRP4and Wnt1in two groups.    Results   The expression of DKK1was significantly lower in SCC group than that in NC group (P<0.05). The expression levels of SFRP4and Wnt1were significantly higher in SCC group than those of NC group (P<0.05). There were significant differences in the expressions of DKK1，SFRP4and Wnt1between samples of different clinical staging, differentiation, sizes of tumor and lymph node metastasis (P<0.05). The expression of DKK1was negatively correlated with SFRP4and Wnt1in SCC group (P<0.05). The expression of SFRP4was positively correlated with Wnt1in SCC group (P<0.05).    Conclusion     The roles of SFRP4and Wnt1are synergistic interactions in the development of SCC. DKK1is an inhibiting factor of SCC

Key words: uterine cervical neoplasms, carcinoma, squamous cell, Wnt1 protein, immunohistochemistry, dickkopf 1, SFRP4