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41例迟发型系统性红斑狼疮患者临床特点分析

王玲1,齐文成2   

  1. 1. 天津市第一中心医院风湿免疫科
    2. 天津市第一中心医院
  • 收稿日期:2010-04-26 修回日期:2010-08-05 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 齐文成

Analysis of Clinical Features in 41 Cases with Late-Onset Systemic Lupus Erythematosus

WANG Ling1, 2   

  1. 1. Department of Rheumatic&Immunology ,Tianjin First Center Hospital
    2.
  • Received:2010-04-26 Revised:2010-08-05 Published:2010-12-15 Online:2010-12-15

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摘要： 目的：探讨老年发病的系统性红斑狼疮的临床特征。方法：回顾分析41例2007-2009年间老年系统性红斑狼疮住院患者的临床表现，实验室指标及并发症情况，并随机抽取同期81例发病年龄<50岁的患者进行比较。结果：与对照组相比，老年组患者女：男显著降低（p<0.01）； 出现纳差、肌痛肌无力、乏力、体重下降、肺损害、继发干燥综合征及类风湿因子（RF）、抗Ro抗体（SSA）阳性比例明显升高（p<0.05）；但狼疮肾炎、光过敏、血液学损害、蝶型红斑、抗双链DNA(dsDNA)抗体滴度升高及补体C3、C4降低的发生率则低于对照组（p<0.05）。结论：与中青年SLE患者相比，老年发病的SLE患者症状多不典型，疾病活动指数低，但存在较多并发症。

关键词: 系统性红斑狼疮, 迟发型, 临床表现, 实验室检查, 并发症

Abstract: Objective：To examine the clinical features of patients with late oneset systemic lupus erythematosus (LOSLE). Methods：41 cases with LOSLE between 2007 and 2009 were reviewed and analyzed ，and compaired with 81 patients who developed SLE below 50 by matching their clinical manifestations, laboratory data and complications. Results：Compaired with the control group, the LOSLE group had a lower female to male ratio(p<0.01); but the incidences of anorexia、myalgia、anergy、weight descent、pulmonary involvement、secondary sjogren syndrome and positive RF、positive anti-SSA were significant higher (p<0.05); the incidences of lupus nephritis、photo sensitivity、anemia、leukopenia、platelet cytopenia、malar rash、positive anti-dsDNA and low complement were significant lower (p<0.05). Conclusion：compared with young and middle-aged SLE patients, the clinical manifestations of LOSLE patients’ are atypical, SLEDAI scores are lower, but complications more than the former.

Key words: systemic lupus erythematosus, late oneset, clinical manifestations, laboratory data, complications