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MMP-3 5A/6A 基因多态性在急性冠脉综合征中的作用

杜纪兵1,赵莉莉。2,黄体钢3,高静4,丛洪良5,毛用敏4,孟冬梅6,刘寅4,崔让庄4,陈树涛4   

  1. 1. 天津市胸科医院CICU科
    2. 天津市胸科医院心研所
    3. 天津医科大学第二医院 心脏科
    4. 天津市胸科医院
    5. 天津市胸科医院心内科
    6. 天津市胸科医院心外监护
  • 收稿日期:2010-02-08 修回日期:2010-03-05 出版日期:2010-11-15 发布日期:2010-11-15
  • 通讯作者: 丛洪良

Function of MMP-3 5A/6A polymorphism on acute myocardial syndrome

  • Received:2010-02-08 Revised:2010-03-05 Published:2010-11-15 Online:2010-11-15

摘要: 【摘要】 目的 研究MMP-3启动子区域5A/6A基因多态性是否参与急性冠脉综合征发生发展过程。方法 随机入选389名患者,根据临床症状及冠脉造影检查结果分为ACS组(n=232名)和对照组(n=157),分别留取两组患者临床资料及血液学标本进行基因多态性检测和MMP-3含量测定。结果 通过对比两组患者基因多态性分布发现,ACS组携带突变型基因型患者(5A/6A+5A/6A)比例明显高于对照组(36.21% vs 24.84% P=0.001);同样从基因频率角度而言,ACS组携带MMP-3 5A等位基因频率也明显高与对照组(37.93% vs 13.06 P<0.001)。另外,对比 ACS组和对照组MMP-3血清含量发现,ACS组MMP-3含量明显高与对照组(12.37±2.96 vs 9.59±2.77 P=0.002)。结论 携带MMP-3 5A等位基因患者更容易导致动脉粥样硬化斑块的破裂,从而即发急性冠脉综合征的发生。

关键词: 基质金属蛋白酶-3, 基因多态性, 急性冠脉综合征

Abstract: 【Abstract】 Objective In order to find the relationship between MMP-3 5A/6A polymorphism and acute myocardial syndrome. Methods 389 patients were divided into ACS group (n=232) and control group (n=157) according to clinical syndrome and coronary angiography result after admission. Collected two groups’ clinical data and blood sample to test and compare. Results Compare two groups polymorphism we found the rate of patients who carried 5A/6A+5A/6A gene type in ACS group significant higher than control group(36.21% vs 24.84% P=0.001), and 5A allele frequency also higher in ACS group than in control group(37.93% vs 13.06 P<0.001). on the other sides compared the MMP-3 serum content between two groups we also found the same result(12.37±2.96 vs 9.59±2.77 P=0.002).Conclusions The patient who carried MMP-3 5A allele trend to occur ACS than other patients.

Key words: matrix metalloproteinase-3, polymorphism, acute myocardial infarction