天津医药

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STAT3、VEGF蛋白在涎腺腺样囊性癌中表达及对血管生成的影响.

张果   

  1. 河北北方学院附属第一医院；河北北方学院
  • 收稿日期:2011-07-06 修回日期:2012-01-11 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 张果

  • Received:2011-07-06 Revised:2012-01-11 Published:2012-06-15 Online:2012-06-15

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摘要： 摘要 目的：探讨STAT3和VEGF蛋白在涎腺腺样囊性癌（Salivary adenoid cystic carcinoma SACC）组织中的表达情况及其与涎腺腺样囊性癌临床病理参数、血管生成的关系。方法：采用免疫组化法检测50例SACC和15例正常腮腺组织中STAT3、VEGF蛋白表达和微血管密度。结果：1.在SACC组织中STAT3及VEGF蛋白表达阳性率分别为66%（33/50）、72%（36/50），在正常腮腺组织中STAT3及VEGF蛋白表达的阳性率分别为,6.7%（1/15）、20%（3/15）,差异有统计学意义（P<0.05）。2.STAT3、VEGF蛋白表达与SACC临床病理分型、有无淋巴结转移、TNM分期有关（P<0.05），而与性别、年龄、肿瘤部位无关（P>0.05）； 3.STAT3与VEGF表达呈正相关（r=0.305.P<0.05）。结论 ：STAT3可能通过上调VEGF表达，促进SACC中新生血管的形成，STAT3可能会成为SACC的抗血管生成的治疗靶点。

关键词: 涎腺腺样囊性癌, STAT3, VEGF, 微血管密度

Abstract: Abstract：Objective To investigate the expression of STAT3 and VEGF in Salivary adenoid cystic carcinoma and explore its relation to clinicopathological parameters and tumor angiogenesis. Methods STAT3 and VEGF expression in Salivary adenoid cystic .carcinoma were studied by immunohistochemistry in samples of tumor tissue from 50 patients with Salivary adenoid cystic carcinoma and those of normal parotid gland tissue from 15 healthy individuals. Results 1 The expression of STAT3 and VEGF protein are concerned with lymph node metastasis ,distant metastasis ,T stage and TNM stage(p all<0.05),its with gender and age are irrelevant(p all>0.05), 3 positive correlation was found between STAT3 and VEGF in Salivary adenoid cystic .carcinoma(r=0.305. P<0.05). Conclusion By raising VEGF, STAT3 might promoted in Salivary adenoid cystic carcinoma of the formation of new blood vessels .Inhition of STAT3 pathway maybe a new way to prevent angiogensis of Salivary adenoid cystic .carcinoma.

Key words: Salivary adenoid cystic carcinoma, STAT3, VEGF, MVD