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根除幽门螺杆菌后胃黏膜肠上皮化生的变化

王锐1,姜葵1,王邦茂1,章明放2,张彦敏1   

  1. 1. 天津医科大学总医院
    2. 天津医科大学
  • 收稿日期:2010-08-11 修回日期:2010-11-29 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 姜葵

The Changes of Gastric Intestinal Metaplasia after Helicobacter pylori eradication

  • Received:2010-08-11 Revised:2010-11-29 Published:2011-04-15 Online:2011-04-15

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摘要： 摘要 目的：探讨根除幽门螺杆菌慢性感染对胃黏膜肠上皮化生的远期疗效。方法：随访319例肠上皮化生的患者，其中根除组182例，未根除组137例，分析不同程度胃黏膜肠上皮化生随时间变化的情况。结果：轻度肠上皮化生在Hp根除后13～36个月和37～70个月与未根除组比较差异有统计学意义（P<0.05或 P<0.01）。中度肠上皮化生仅在Hp根除后37～70个月与未根除组比较差异有统计学意义（P<0.05）。重度肠化在随访的6～70个月内差异均无统计学意义（P>0.05）。结论：轻中度胃黏膜肠上皮化生患者根除根除幽门螺杆菌慢性感染后可获远期疗效。

关键词: 幽门螺杆菌, 肠化, 逆转

Abstract: Abstract Objective To investigate chronic long-term effect of gastric intestinal metaplasia after the eradication of Helicobacter pylori. Method the total 319 cases of intestinal metaplasia, including 182 cases of the eradication group and 137 cases remained Helicobacter pylori positive were analyzed the changes with the time. results Mild intestinal metaplasia in patients are significant difference compared with non-eradication group after 12～36 months and 36～70 months, the P values of comparison of two groups are P<0.05 ,P<0.01 respectively. There are a significant difference between two groups in patients with moderate intestinal metaplasia from 36 to 70 months after H. pylori eradication（P<0.05）, Severe intestinal metaplasia did not changed within seventy months after H. pylori eradication (P> 0.05). Conclusion The patients with mild and moderate gastric intestinal metaplasia after eradication of Helicobacter pylori can receive long-term effect.

Key words: Helicobacter pylori, Intestinal metaplasia, Reversibility

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