天津医药

• 细胞与分子生物学 • 上一篇    下一篇

CXCL12/CXCR7对胃癌生长、粘附、侵袭的影响

张娜，1,辛琪2,张传山2   

  1. 1. 天津市大港医院病理科
    2. 天津市第三中心医院
  • 收稿日期:2013-12-26 修回日期:2014-04-20 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 辛琪

The role of CXCL12/CXCR7 on the proliferation,adhesion and invasion of gastric cancer

  • Received:2013-12-26 Revised:2014-04-20 Published:2014-09-15 Online:2014-09-15
  • Contact: XINqi

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摘要： 目的：运用免疫组化方法研究CXCL12/CXCR7在胃癌组织中的表达，并选取与粘附、侵袭有关的几个细胞因子进行相关性研究，揭示CXCR7与胃癌生长、粘附及侵袭的关系。方法：收集160例胃腺癌病人的癌组织和30例正常胃组织，采用免疫组化方法，检测CXCL12/CXCR7、Survivin、CD44v6、MMP-3在胃癌和正常组织中的表达，并用统计学方法分析其相关性。结果：CXCL12/CXCR7在胃癌组织中的表达明显高于对照组正常胃组织（P=0.000），并且其在胃癌中的表达与胃癌的大小、浸润深度、是否有淋巴结转移及临床分期有关（P﹤0.05）。在胃癌组织中CXCR7表达与Survivin、CD44v6及MMP-3呈正相关。结论：CXCR7通过抗凋亡(Survivin)参与胃癌的生长，在胃癌的粘附及侵袭过程中通过CD44V6及MMP-3发挥作用，并可能参与胃癌的淋巴结转移。

关键词: 胃癌, CXCR7蛋白, 趋化因子, 免疫组化

Abstract:

[Abstract] Objective To investigate the expression of CXCR7in gastric carcinoma tissues and the role of CXCR7 in tumor growth, adhesion and invasion of gastric cancer. Methods The expression levels of CXCR7, Survivin, CD44v6and matrix metalloproteinase (MMP)-3were detected by immunnohistochemistry method in gastric cancer specimens came from 160patients (gastric cancer group) and30specimens of normal gastric tissues (control group).Results The expression of CXCR7protein was significantly higher in gastric cancer group than that of control group (P<0.05). The positive CXCR7 staining was significantly different with tumor size, depth of invasion, lymph node metastasis and clinical staging (P<0.05). CXCR7expression was positively correlated with Survivin, CD44v6and MMP-3. Conclusion CXCR7might take part in progression of gastric cancer by anti-apoptosis (Survivin). CXCR7might take part in the lymph node metastasis of gastric cancer and mediate the adhesion and invasion by CD44v6and MMP-3.

Key words: gastric cancer, CXCR7, Chemokine receptor, immunnohistochemistry