天津医药

• 临床研究 • 上一篇    下一篇

新疆维族急性冠脉综合征患者血管内皮功能与脉压指数的相关性

杨阳   

  1. 新疆维吾尔自治区人民医院
  • 收稿日期:2013-10-31 修回日期:2014-05-27 出版日期:2014-10-15 发布日期:2014-10-15
  • 通讯作者: 杨阳

Correlation between Endothelial Function with Pulse Pressure Index in Uygur Patients with Acute Coronary Syndrome

YANG Yang   

  1. Department of Cardiology, the People’s Hospital of Xinjiang Urgur Autonomous Region，Wulumuqi 830000 , China
  • Received:2013-10-31 Revised:2014-05-27 Published:2014-10-15 Online:2014-10-15
  • Contact: YANG Yang

PDF (PC)

2857

摘要：

【摘要】目的 研究新疆维吾尔族(维族)急性冠脉综合征（ACS）患者血管内皮功能的变化及其与脉压指数(PPI) 的相关性。方法 选取经冠状动脉造影确诊为ACS 的维族患者208 例(研究组)及同期住院经冠状动脉造影排除冠心病的维族患者157 例(对照组)，于入院时测量身高、体质量、血压，记录主要基础疾病史。取空腹肘正中静脉血，测量空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)；采用酶联免疫吸附法测定血浆血管性假性血友病因子(vWF)及凝血因子Ⅷ(CFⅧ)水平。结果 2 组年龄、性别、高血压病史、糖尿病病史、吸烟史、饮酒史、体质量指数、PPI、HDL-C 和FBG 差异均无统计学意义。研究组收缩压、舒张压、脉压、TG、TC、LDL-C 以及vWF、CFⅧ水平均高于对照组（均P＜0.05）。血浆vWF、CFⅧ水平与脉压、PPI 均呈正相关，且vWF 与CFⅧ水平也呈正相关(均P＜0.01)。结论 新疆维族ACS 患者血管内皮功能明显受损，且血管内皮受损程度与脉压、PPI 呈正相关，脉压和PPI 可间接评价血管内皮功能。

关键词: 急性冠脉综合征, 脉压指数, 内皮功能, 维吾尔族, 血管性假性血友病因子

Abstract:

[Abstract] Objective  To investigate the correlation of endothelial function variation with pulse pressure index in Uygur acute coronary syndrome patients in Xinjiang. Methods  Uygur patients were divided into acute coronary syndrome group (n=208) and control group (n=157) according to their Coronary angiography results. Height, weight and blood pressure were measured on admission and basic medical history were recorded. Fasting blood glucose (FBG), three acyl glycerin (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL - C), low density lipoprotein cholesterol (LDL - C) were examined using fasting venous blood; Plasma Coagulation Factor Ⅷ (CFⅧ) and von Willebrand factor（vWF）were examined using ELISA. Results  There are no statistical difference in age, gender, history of hypertension, diabetes history, history of smoking, drinking, body mass index, PPI, HDL - C and FBG between two groups. The systolic pressure, diastolic blood pressure, pulse pressure, TG, TC, LDL - C and vWF, CF Ⅷ levels in acute coronary syndrome group were higher than those in the control group (all P < 0.05). The levels of plasma vWF and CFⅧ were positively correlated with pulse pressure and PPI, it also was positively correlated between the levels of plasma vWF and CFⅧ (P < 0.01). Conclusion  The endothelial function was significantly impaired in Xinjiang Uygur patients with acute coronary syndromes, and vascular endothelial damage was positively correlated with pulse pressure and PPI. The pulse pressure and PPI can be used to evaluate the vascular endothelial function indirectly.

Key words: Acute coronary syndromes, pulse pressure index, endothelial function, Uygur race, vWF